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Serious complications during heart rhythm ablation for ventricular tachycardia or extra heartbeats

Studies serious ablation problems in ventricular tachycardia or extra heartbeats.

Key facts

Who runs it
University Hospital, Basel, Switzerland
Where
Chicago and Michigan Center, United StatesSee the 2 sitesAlso in 15 other countries, 23 sites
Trial code
Registry title
Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation
Status
Recruiting
People taking part
15,000 people, planned
Started
1 Jul 2024
Expected to end
31 Dec 2028
Type of study
Observational
Record updated
20 August 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for existing records of people who had a serious complication during ablation for ventricular tachycardia (VT) or premature ventricular complexes (PVC). Ablation is a procedure that destroys small areas of heart tissue that cause abnormal beats. Data come from participating centers.

Age
Older than 18 years.
Sex
Females and males can join.
Disease stage
People who had any type of VT/PVC ablation, first or repeat, with a severe complication. Examples: unstable blood pressure needing intensive care, tamponade, stroke, cardiac arrest, heart attack, phrenic nerve palsy, major bleeding needing transfusion, complications needing surgery, or death.
Earlier treatment
VT/PVC ablation as routinely done by the participating centers. Repeat procedures are accepted.

Main reasons for not taking part

  • Centers that refuse to take part.
  • Datasets with less than 10 procedures (no single case reports).
  • Missing key baseline details or not enough details about each complication.
  • Data from randomized controlled trials are not collected.

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Centers : Centers participating in the present collaborative study group. Invitation to participate will be based either upon personal referral of one of the investigator, previous collaboration or based on a meta-analytic review of the literature published on the subject within the past 20 years
  • Patients: Females and males of >18 years undergoing any type of VT/PVC ablation. While we will accept redo-procedure we will ask for a unique patient-identifier to link procedures belonging to the same patients together
  • Interventions: VT/PVC ablation (first intervention or re-do) as routinely performed by the participating centers
  • Outcomes: Severe complications, defined as hemodynamic instability requiring mechanical intensive-care management, tamponade, stroke, cardiac arrest, myocardial infarction, phrenic nerve palsies, major bleeding requiring transfusion, vascular or cardiac complication requiring surgery, procedure-related death
  • Setting: Observational cohort studies, registries, retrospective cohort studies. Data stemming from RCTs (Randomized controlled trials) will not be collected as they likely do not represent a "real-life" setting
  • Length of follow-up: Peri-procedural complications
  • Years considered: Not limited to a specific time-frame, but to reflect common ablation practices, we will focus on data from the 20 past years
  • Number of patients provided : No lower limit of patients provided per dataset or ablation volume per year to include high- as well as low-volume centers

Who cannot take part

  • Refusal of the center to participate
  • Less than 10 procedures available in the dataset (no case reports)
  • Missing essential baseline characteristics, missing collection of sufficient details regarding each complication

Where in United States

Also in 15 other countries, 23 sites

  • Rush University Medical CenterChicago, United StatesContact: Henry HuangTaking people
  • University of MichiganMichigan Center, United StatesContact: Jackson LiangTaking people

About the trial

What the trial wants to find out

The investigators aim to characterize patients presenting with a severe ventricular tachycardia (VT) and premature ventricular complex (PVC)-ablation-related complication including patient characteristics, procedural details and subsequent management of the complication by gathering existing patient-level data.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation - an International Multicenter Collaborative Study Group
Plain-language title
Serious complications during heart rhythm ablation for ventricular tachycardia or extra heartbeatsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
20 August 2026