Vitamin C and vitamin E for brain inflammation in adults with obesity
Tests vitamin C, vitamin E, or both in Mexican adults with obesity.
Plain-language title generated from the registry record
Registry title: Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity
Key facts
- Where
- Cuernavaca, MexicoSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 59 years old?
Source: NCT07782411, who can take part
Where in Mexico
- University Medical Center, Universidad Autónoma del Estado de MorelosCuernavaca, MexicoNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Autonomous University of Morelos
- Trial code
- NCT07782411
- Record updated
- 24 August 2026
- Original description
This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with obesity.Read full original descriptionShow less
Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity
This clinical trial will determine whether taking ascorbic acid (vitamin C), α-tocopherol (vitamin E), or both together can lower markers of brain inflammation and change the expression of neuropeptides in Mexican adults with obesity.
Main Questions
The study aims to answer:
1. Does vitamin C, vitamin E, or both reduce neuroinflammation? 2. Do these supplements change the expression of neuropeptides linked to obesity? Comparison Groups Researchers will compare the effects of vitamin C alone, vitamin E alone, and the combination of both to see if they improve brain health in people with obesity.
What Participants Will Do
Participants will:
1. Take vitamin C, vitamin E, or both daily, depending on their assigned group 2. Attend clinic visits once every 2 weeks for and tests for checkups and tests for record and report supplement intake so that researchers can monitor and evaluate treatment adherence 3. Provide samples and health information to measure inflammation and neuropeptides , at the beginning of the intervention and at 12 weeks, when the intervention ends.
Inclusion: Adults aged 40 to 59 years, Mexican men and women; Obese group: Body mass index (BMI) > 30 kg/m²; body fat percentage > 25% in men and > 35% in women; waist circumference > 90 cm in men and > 80 cm in women; Non-obese group: BMI < 24.9 kg/m²; body fat percentage < 25% in men and < 35% in women; waist circumference < 90 cm in men and < 80 cm in women; Willingness to sign the informed consent form.
Exclusion: Individuals with renal diseases, hepatic diseases, or those under pharmacological treatment for any condition associated with acute inflammation; Individuals currently undergoing treatment for obesity (pharmacological, nutritional, or physical activity programs); Individuals taking dietary supplements or multivitamins.