Magnetic brain stimulation and motor responses in people with severe arm weakness after stroke
Tests one session of magnetic brain stimulation in adults with severe arm weakness after stroke.
Plain-language title generated from the registry record
Registry title: Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)
Key facts
- Where
- Palma, SpainSee the site
Where in Spain
- Hospital Sant Joan de Déu PalmaPalma, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ancor Rebassa Cabrera
- Trial code
- NCT07787793
- Record updated
- 26 August 2026
- Original description
The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment.Read full original descriptionShow less
Effects of a Single Session of High-Frequency Repetitive Transcranial Magnetic Stimulation on Cortical Mapping of the Upper Limb in Stroke Patients With Severe Upper Limb Impairment
The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment.
The main question it aims to answer is:
Does one session of high-frequency rTMS increase the number of motor evoked potential (MEP)-positive points in the cortical motor map of the affected hemisphere compared to sham stimulation?
Researchers will compare high-frequency rTMS (10 Hz, 600 pulses) applied over the affected motor cortex to sham stimulation to see if rTMS increases detectable cortical motor responses in patients who have little or no voluntary hand movement after stroke.
Participants will:
Undergo a cortical motor mapping assessment before the intervention. Receive either one session of real rTMS or sham stimulation, depending on their randomly assigned group.
Undergo a second cortical motor mapping assessment immediately after the intervention.
Inclusion: First-ever stroke confirmed by MRI or CT scan; Inability to voluntarily activate the hand musculature:; manual muscle testing score of 1 or less in finger extension; Time since stroke onset greater than 6 months.
Exclusion: History of craniotomy or metallic implants in the skull; Diagnosis of uncontrolled epilepsy; Diagnosis of other neurological diseases (dementia, Parkinson's disease, neuropathies, multiple sclerosis, or similar conditions); Low level of consciousness or significant cognitive impairment that prevents informed consent or study collaboration; Diagnosis of rheumatic disease or presence of hand deformities; Pregnancy.