Surgery Through the Nose for Tumors at the Base of the Skull
Looks at results of nose-route endoscopic surgery for skull base tumors.
Plain-language title generated from the registry record
Registry title: Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions.
Key facts
- Where
- Asyut, EgyptSee the site
Where in Egypt
- Assiut UniversityAsyut, EgyptNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT07788300
- Record updated
- 26 August 2026
- Original description
Aim of this study is to evaluate the surgical and functional outcomes of the extended endoscopic endonasal approach (EEEA) in the management of skull base lesions, including extent of resection, postoperative complications, and clinical outcomes.Read full original descriptionShow less
Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions.
Aim of this study is to evaluate the surgical and functional outcomes of the extended endoscopic endonasal approach (EEEA) in the management of skull base lesions, including extent of resection, postoperative complications, and clinical outcomes.
Inclusion: 1. Adult patients aged 18 years or older. 2. Patients with radiologically confirmed skull base lesions (based on MRI ± CT) involving the anterior, middle, or posterior skull base; Patients undergoing lesion resection using the extended endoscopic endonasal approach (EEEA); Lesions amenable to endoscopic endonasal access, including: Pituitary adenomas with extrasellar extension Craniopharyngiomas Skull base meningiomas Chordomas and other midline skull base lesions 5. Availability of complete preoperative assessment, including: Clinical evaluation Neuro-ophthalmological assessment (when applicable) Radiological imaging 6. Availability of detailed intraoperative data, including surgical approach and intraoperative findings; Availability of early postoperative MRI (within 72 hours to 3 months) to assess the extent of resection; Patients with adequate postoperative follow-up (minimum 3 months) for evaluation of outcomes and complications.
Exclusion: 1. Patients aged less than 18 years. 2. Patients who underwent transcranial approaches. 3. Lesions not primarily involving the skull base or not suitable for endoscopic endonasal access; Patients with incomplete clinical, radiological, or operative data. 5. Absence of early postoperative MRI, making assessment of the extent of resection unreliable; Patients with insufficient follow-up (less than 3 months). 7. Cases managed by biopsy only without attempted lesion resection. 8. Patients with severe comorbidities significantly affecting surgical outcome (e.g., advanced systemic disease), if they introduce bias in outcome assessment.