Studying the Immune System's Role in Neuropsychiatric Symptoms
Looks for immune signs in blood of people with suspected immune-related neuropsychiatric symptoms.
Plain-language title generated from the registry record
Registry title: Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
Key facts
- Where
- London, United KingdomSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 100 years old?
Source: NCT07791212, who can take part
Where in United Kingdom
- King's College HospitalLondon, United KingdomNo longer taking part
- South London and Maudsley NHS Foundation TrustLondon, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- King's College London
- Trial code
- NCT07791212
- Record updated
- 27 August 2026
- Original description
The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment of immune-related neuropsychiatric disorders in individuals aged 16-100 years with suspected immune-mediated neuropsychiatric symptoms and matched control participants without neuropsychiatric symptoms.Read full original descriptionShow less
Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment of immune-related neuropsychiatric disorders in individuals aged 16-100 years with suspected immune-mediated neuropsychiatric symptoms and matched control participants without neuropsychiatric symptoms.
The main questions it aims to answer are what immunological mechanisms are associated with neuropsychiatric symptoms across a range of neurological, psychiatric, autoimmune, infectious, and inflammatory conditions. Also, if immunological biomarkers can be identified that may support the diagnosis, prognosis, and future treatment of neuropsychiatric disorders in which the immune system may play a role.
Participants will provide a blood sample for immunological analysis and may optionally provide a cerebrospinal fluid (CSF) sample if a suitable previously collected sample is not available. Researchers may also analyse existing clinical and biological samples where available. Participants will provide demographic and clinical information, allow access to relevant medical record data, and may optionally provide additional blood samples, up to four times within one year, for further biomarker and immunological analyses.
Inclusion: Participants with Neuropsychiatric symptoms; Age 16-100; Current or previous neuropsychiatric symptoms within the last year; Suspicion of immunological contribution to the aetiology of their neuropsychiatric symptoms; Control Participants; Age 16-100; No current or previous self-report of neuropsychiatric symptoms within the last year; Optional Lumbar Puncture only:; Documented full blood count within the last 3 months with no clinically significant abnormalities.
Exclusion: Significant lower spinal deformity (such as spina bifida), injury, or disease (such as stenosis) or previous lower spinal surgery; Antiplatelet or anticoagulant therapy within the 14 days prior to Lumbar Puncture procedure; Known or suspected clotting disorder; Known or suspected allergy to local anaesthetic agent or an ingredient of the anaesthetic solution; History of chronic or recurrent headaches, in the opinion of the investigator; Clinically significant abnormality in full blood count; All Participants:; Unacceptable risk of harm to participant or study staff due to risk of behavioural disturbance; Inability to have blood tests; Optional Lumbar Puncture only:; Known or suspected raised intracranial pressure, assessed by study clinician.