Heart scan guided choice of pacemaker type in non-ischemic cardiomyopathy with heart failure
Compares two pacing devices in adults with non-ischemic cardiomyopathy, sorted by heart scan risk.
Plain-language title generated from the registry record
Registry title: Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronisation Therapy
Key facts
- Where
- Madurai, IndiaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with heart failure from non-ischemic cardiomyopathy, a typical left bundle branch block and a weak pumping heart (LVEF 35% or lower) who still have symptoms despite medicines.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Typical left bundle branch block (Strauss criteria) with LVEF ≤35% and heart failure symptoms despite guideline directed medical therapy (GDMT)
- Earlier treatment
- Must still have heart failure symptoms despite guideline directed medical therapy (GDMT)
Main reasons for not taking part
- Significant coronary artery disease needing revascularisation
- Uncorrected congenital or valvular heart disease
- Expected life expectancy under 12 months
- Contrast allergy, or kidney problems that prevent MRI with contrast
- Pregnant or breastfeeding women
Read by machine on 12 November 2026.
Where in India
- Velammal Medical College Hospital and Research InstituteMadurai, IndiaContact: Shunmuga Sundaram Ponnusamy, MD,, FHRSTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Velammal Medical College Hospital and Research Institute
- Trial code
- NCT07791407
- Record updated
- 27 August 2026
- Original description
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk categorized by CMR imaging.Read full original descriptionShow less
Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronization Therapy (MADURAI CRT)
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk categorized by CMR imaging.
Inclusion: Patients with age ≥18 years; Typical left bundle branch block as defined by Strauss criteria with LVEF ≤35%; Heart failure symptoms despite guideline directed medical therapy (GDMT).
Exclusion: Patients with associated uncorrected congenital or valvular heart disease; Patients with contrast allergy; Patients with angiographic evidence of significant coronary artery disease requiring revascularisation. In patients with significant CAD, LVEF will be re-assessed 3 months after revascularisation to decide about CRT; Expected life-expectance of <12 months due to associated comorbidities; Baseline non-LBBB morphology; Renal dysfunction which limits the acquisition of CMR with contrast; Pregnant or lactating women; Patients who are unable to comply with study protocol.