Taking people in ChinaPhase 2/3

Tests BR005-036C tablets against placebo for acute migraine in adults

Compares BR005-036C tablets with placebo in adults having acute migraine attacks.

Plain-language title generated from the registry record
Registry title: Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in Adults

Key facts

Where: Anhui, Beijing, Chongqing, Fujian, Gansu, Guangdong, Guangzhou, Hebei, Heilongjiang, Henan, Hubei, Hunan, Inner Mongolia, Jiangsu, Jilin City, Liaoning, Ningxia, Shandong, Shanghai, Shanxi, Sichuan, Tianjin, Xinjiang, Yunnan, and Zhejiang, ChinaSee the 83 sites
Phase: Phase 2/3

Where in China

the First Affiliated Hospital of Bengbu Medical CollegeAnhui, ChinaNot yet recruiting
The Second Affiliated Hospital of Anhui Medical UniversityAnhui, ChinaNot yet recruiting
The Second People's Hospital of HefeiAnhui, ChinaNot yet recruiting
Xuancheng People's HospitalAnhui, ChinaNot yet recruiting
Beijing Friendship Hospital, Capital Medical UniversityBeijing, ChinaNot yet recruiting
First Medical Center of Chinese PLA General HospitalBeijing, ChinaTaking people
Peking Union Medical College HospitalBeijing, ChinaNot yet recruiting
Peking University People's HospitalBeijing, ChinaNot yet recruiting
Peking University Third HospitalBeijing, ChinaNot yet recruiting
Xuanwu Hospital, Capital Medical UniversityBeijing, ChinaNot yet recruiting
Chonggang General HospitalChongqing, ChinaNot yet recruiting
Chongqing University Three Gorges HospitalChongqing, ChinaNot yet recruiting
The First Affiliated Hospital of Chongqing Medical UniversityChongqing, ChinaNot yet recruiting
The Fourth People's Hospital of Chongqing (Chongqing Emergency Medical Center)Chongqing, ChinaNot yet recruiting
The First Affiliated Hospital of Xiamen UniversityFujian, ChinaNot yet recruiting
The 940th Hospital of PLA Joint Logistic Support ForceGansu, ChinaNot yet recruiting
The Second Hospital of Lanzhou UniversityGansu, ChinaNot yet recruiting
Guangzhou First People's HospitalGuangdong, ChinaNot yet recruiting
Shenzhen People's HospitalGuangdong, ChinaNot yet recruiting
Shenzhen Second People's HospitalGuangdong, ChinaNot yet recruiting
The Second Affiliated Hospital of Guangzhou Medical UniversityGuangdong, ChinaNot yet recruiting
Guangdong Provincial People's HospitalGuangzhou, ChinaNot yet recruiting
Cangzhou Central HospitalHebei, ChinaNot yet recruiting
Hebei General HospitalHebei, ChinaNot yet recruiting
The Fourth Affiliated Hospital of Harbin Medical UniversityHeilongjiang, ChinaNot yet recruiting
The First Affiliated Hospital of Henan University of Science and TechnologyHenan, ChinaNot yet recruiting
The First Affiliated Hospital of Nanyang Medical CollegeHenan, ChinaNot yet recruiting
The First Affiliated Hospital of Zhengzhou UniversityHenan, ChinaNot yet recruiting
The Second People's Hospital of ZhengzhouHenan, ChinaNot yet recruiting
Zhengzhou People's HospitalHenan, ChinaNot yet recruiting
Huanggang Central HospitalHubei, ChinaNot yet recruiting
Jingzhou First People's HospitalHubei, ChinaNot yet recruiting
Renmin Hospital of Wuhan UniversityHubei, ChinaNot yet recruiting
Taihe Hospital, ShiyanHubei, ChinaNot yet recruiting
Wuhan Third Hospital (Wuhan Tongren Hospital)Hubei, ChinaNot yet recruiting
Zhongnan Hospital of Wuhan UniversityHubei, ChinaNot yet recruiting
Changde First People's HospitalHunan, ChinaNot yet recruiting
Changsha Central HospitalHunan, ChinaNot yet recruiting
Shaoyang Central HospitalHunan, ChinaNot yet recruiting
The Second Xiangya Hospital of Central South UniversityHunan, ChinaNot yet recruiting
The Third Hospital of ChangshaHunan, ChinaNot yet recruiting
The Third Xiangya Hospital of Central South UniversityHunan, ChinaNot yet recruiting
Xiangya Hospital of Central South UniversityHunan, ChinaNot yet recruiting
Zhuzhou Central HospitalHunan, ChinaNot yet recruiting
Inner Mongolia Autonomous Region People's HospitalInner Mongolia, ChinaNot yet recruiting
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyInner Mongolia, ChinaNot yet recruiting
Jiangsu Province Hospital (The First Affiliated Hospital of Nanjing Medical University)Jiangsu, ChinaNot yet recruiting
Nanjing Brain HospitalJiangsu, ChinaNot yet recruiting
The First Affiliated Hospital of Soochow UniversityJiangsu, ChinaNot yet recruiting
The Second Affiliated Hospital of Nanjing Medical UniversityJiangsu, ChinaTaking people
The Second Affiliated Hospital of Soochow UniversityJiangsu, ChinaNot yet recruiting
The Second People's Hospital of LianyungangJiangsu, ChinaNot yet recruiting
Wuxi People's HospitalJiangsu, ChinaNot yet recruiting
The Second Hospital of Jilin UniversityJilin City, ChinaNot yet recruiting
Dalian Municipal Central Hospital, Affiliated to Dalian University of TechnologyLiaoning, ChinaNot yet recruiting
General Hospital of Northern Theater Command of Chinese PLALiaoning, ChinaNot yet recruiting
The People's Hospital of Liaoning ProvinceLiaoning, ChinaNot yet recruiting
The First People's Hospital of YinchuanNingxia, ChinaNot yet recruiting
Affiliated Hospital of Jining Medical UniversityShandong, ChinaNot yet recruiting
Jinan Central HospitalShandong, ChinaNot yet recruiting
Liaocheng People's HospitalShandong, ChinaNot yet recruiting
Qilu Hospital of Shandong UniversityShandong, ChinaNot yet recruiting
Qingdao Central HospitalShandong, ChinaNot yet recruiting
Rizhao People's Hospital of Shandong ProvinceShandong, ChinaNot yet recruiting
The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital)Shandong, ChinaNot yet recruiting
Zaozhuang Municipal HospitalShandong, ChinaNot yet recruiting
Huashan Hospital, Fudan UniversityShanghai, ChinaNot yet recruiting
Shanghai Fourth People's HospitalShanghai, ChinaNot yet recruiting
Baoji Central HospitalShanxi, ChinaNot yet recruiting
Shaanxi Provincial People's HospitalShanxi, ChinaNot yet recruiting
The First Affiliated Hospital of Xi'an Medical UniversityShanxi, ChinaNot yet recruiting
Xi'an Gaoxin HospitalShanxi, ChinaNot yet recruiting
Xianyang Hospital of Yan'an UniversityShanxi, ChinaNot yet recruiting
Dazhou Central HospitalSichuan, ChinaNot yet recruiting
The First People's Hospital of ZigongSichuan, ChinaNot yet recruiting
Tianjin People's HospitalTianjin, ChinaNot yet recruiting
The Second Affiliated Hospital of Xinjiang Medical UniversityXinjiang, ChinaNot yet recruiting
The First Affiliated Hospital of Kunming Medical UniversityYunnan, ChinaNot yet recruiting
The second affiliated hospital of Kunming medical universityYunnan, ChinaNot yet recruiting
Huzhou Central HospitalZhejiang, ChinaNot yet recruiting
Rui'an People's HospitalZhejiang, ChinaNot yet recruiting
Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang, ChinaNot yet recruiting
The Second Affiliated Hospital Zhejiang University School of MedicineZhejiang, ChinaNot yet recruiting

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

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Trial details

Who runs it: Brise Pharmaceuticals Co., Ltd.
Trial code: NCT07792681
Record updated: 23 October 2026
Original description: The purpose of this study is to compare the efficacy and safety of BR005-036C versus placebo in subjects with Acute MigrainesRead full original descriptionShow less
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II/III Clinical Study Evaluating the Efficacy and Safety of BR005-036C Tablets in the Acute Treatment of Migraine in Adults
The purpose of this study is to compare the efficacy and safety of BR005-036C versus placebo in subjects with Acute Migraines
Inclusion: Male or female Participants aged 18 years or older; Patients diagnosed with migraine with or without aura in accordance with the International Classification of Headache Disorders, 3rd Edition (ICHD-3), with a disease history of at least 1 year; Onset age of migraine shall be less than 50 years old; At least 2-8 moderate-to-severe migraine attacks per month within 3 months prior to screening visit; Fewer than 15 headache days (migraine or non-migraine) per month within 3 months prior to screening visit; Patients on prophylactic migraine medication are permitted to remain on therapy provided they have been on a stable dose for at least 3 months prior to study entry.
Exclusion: Patient with a history of acute hepatitis within 6 months prior to screening, or any chronic liver diseases including non-alcoholic fatty liver disease, chronic viral hepatitis, liver cirrhosis; Patient with a history of hematological or solid malignant neoplasms within 5 years prior to screening; History of alcohol or substance abuse within 6 months prior to screening; Use of CGRP receptor antagonists within 1 month prior to screening or randomization; use of anti-CGRP or anti-CGRP-receptor monoclonal antibodies within 6 months prior to screening or randomization; Use of acute migraine treatment medications for more than 10 days per month in 3 months prior to randomization (refer to Concomitant Medications section); Patient with a history of or diagnosed with brainstem aura migraine, hemiplegic migraine, retinal migraine, new-daily-persistent headache, trigeminal autonomic cephalalgias or cranial neuralgia; Patient with clinically significant cardiovascular, cerebrovascular, hematological, endocrine, hepatic, renal, pulmonary, gastrointestinal, neurological or psychiatric disorders; patient with other confounding acute or chronic pain syndromes, dementia, epilepsy, or other diseases (other than migraine) that may interfere with study assessments; Patient with uncontrolled hypertension; Clinically significant laboratory abnormalities at screening: ALT, AST or total bilirubin >1.5 × upper limit of normal (ULN); estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m²; Abnormal electrocardiogram findings at screening: QTcF >450 msec for male subjects; QTcF >470 msec for female subjects.
ClinicalTrials.gov NCT07792681