New Ways to Diagnose Lymphoma and Castleman Disease in People With HIV
Tests new diagnostic methods for swollen lymph nodes in people living with HIV.
Plain-language title generated from the registry record
Registry title: New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease
Key facts
- Where
- Lilongwe, MalawiSee the site
Where in Malawi
- Lighthouse Trust HIV Centers of ExcellenceLilongwe, MalawiTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Indiana University
- Trial code
- NCT07793006
- Record updated
- 28 August 2026
- Original description
Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.Read full original descriptionShow less
New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease
Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.
Inclusion: Age ≥1 year old and body weight of ≥ 10 kg; HIV-infected; Unexplained lymphadenopathy with at least one lymph node ≥2 cm that is amenable to biopsy; Willing and able to give informed consent if the subject is 18 years of age or older, adolescent assent and legal guardian consent for subjects 15-17 years of age, pediatric assent and legal guardian consent for subjects 7-14 years of age, or legal guardian consent for pediatric subjects less than 7 years of age.
Exclusion: Subjects with a previous history of cancer in the last five years with the exception of subjects with Kaposi sarcoma (i.e. history of Kaposi sarcoma is allowed in the study); Cannot or is not willing to follow study procedures.