Association Between Changes in Aortic Valve Area and Pulmonary Congestion After Transcatheter Aortic Valve Implantation
Key facts
- Who runs it
- Istanbul University - Cerrahpasa
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 52 people, planned
- Started
- 31 Mar 2026
- Expected to end
- Apr 2027
- Type of study
- Observational
- Treatments tested
- Transcatheter Aortic Valve Implantation (TAVI)
- Record updated
- 31 August 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Age ≥18 years
- Diagnosis of severe symptomatic aortic stenosis
- Scheduled for elective transfemoral transcatheter aortic valve implantation (TAVI)
- Availability of preprocedural transthoracic echocardiography
- Feasibility of lung ultrasound examination
- Provision of written informed consent
Who cannot take part
- Interstitial lung disease or pulmonary fibrosis
- Acute decompensated heart failure
- Severe exacerbation of chronic obstructive pulmonary disease (COPD)
- Conditions precluding adequate thoracic ultrasound examination
- Active pneumonia
- Massive pleural effusion
- Severe mitral stenosis
- Clinically significant severe mitral regurgitation
- Development of a major complication during the procedure
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This prospective, single-center observational study aims to evaluate the relationship between changes in aortic valve hemodynamics and pulmonary congestion in patients undergoing elective transfemoral transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis. Pulmonary congestion will be assessed non-invasively using lung ultrasound, with particular emphasis on B-lines, at predefined time points before and after TAVI. Changes in aortic valve area and other echocardiographic parameters will be evaluated in relation to changes in lung ultrasound findings. The primary objective is to determine the association between improvement in aortic valve area following TAVI and changes in pulmonary congestion.
The group in the trial
- TAVI Cohort
Patients with severe symptomatic aortic stenosis undergoing elective transfemoral transcatheter aortic valve implantation (TAVI) as part of routine clinical care. Lung ultrasound and echocardiographic assessments will be performed at predefined time points to evaluate changes in pulmonary congestion and aortic valve hemodynamics.
Treatment: Transcatheter Aortic Valve Implantation (TAVI)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Association Between Changes in Aortic Valve Area and Pulmonary Congestion in Patients Undergoing Transcatheter Aortic Valve Implantation
- Record updated
- 31 August 2026