Multiple Nerve Blocks for Pain Control After Off-Pump Heart Bypass Surgery
Tests combined nerve blocks for pain and recovery after off-pump coronary bypass surgery.
Plain-language title generated from the registry record
Registry title: Efficacy of Multiple Nerve Blocks on the Recovery of Patients Undergoing Off Pump CABG Surgeries
Key facts
- Where
- Cairo, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07794527, who can take part
Where in Egypt
- Ain Shams University HospitalsCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ain Shams University
- Trial code
- NCT07794527
- Record updated
- 31 August 2026
- Original description
In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed rehabilitation. While regional fascial plane blocks offer a safer, opioid-sparing alternative, no single technique provides complete analgesia for the complex and multi-dermatomal pain generated by sternotomy, graft harvesting, chest wall retraction, and drain sites. Therefore, a multimodal approach combining blocks such as parasternal nerve block , rectus sheath nerve block and femoral nerve block , may cover most of areas expected to be sources of intraoperative and post-operative pain in cardiac surgery patients.Read full original descriptionShow less
Enhancement of the Recovery Profile in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery Through Combination of Multiple Regional Nerve Blocks
In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed rehabilitation. While regional fascial plane blocks offer a safer, opioid-sparing alternative, no single technique provides complete analgesia for the complex and multi-dermatomal pain generated by sternotomy, graft harvesting, chest wall retraction, and drain sites. Therefore, a multimodal approach combining blocks such as parasternal nerve block , rectus sheath nerve block and femoral nerve block , may cover most of areas expected to be sources of intraoperative and post-operative pain in cardiac surgery patients.
Inclusion: o Scheduled for elective off-pump coronary artery bypass graft (OPCAB) surgery via median sternotomy; American Society of Anesthesiologists (ASA) physical status III - IV; Ability to provide informed consent.
Exclusion: o Emergency or redo cardiac surgery; On-pump CABG or concomitant valve or aortic procedures; Known allergy to local anesthetics or study drugs; Coagulopathy or ongoing anticoagulant therapy contraindicating regional block; Preoperative chronic opioid use or opioid dependency; Neurologic or psychiatric conditions interfering with pain assessment; Infection at the block injection site; Severe hepatic or renal impairment; Body mass index (BMI) > 40 kg/m²; Inability to understand or cooperate with pain scoring or postoperative care.