Two ways to set the bypassed intestine length in gastric bypass for severe obesity
Compares two ways of choosing bypass length in adults with severe obesity.
Plain-language title generated from the registry record
Registry title: TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass
Key facts
- Where
- Almaty, KazakhstanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07796503, who can take part
Where in Kazakhstan
- JSC "National Scientific Center of Surgery named after A.N. Syzganov"Almaty, KazakhstanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Scientific Center of Surgery named after A.N.Syzganov
- Trial code
- NCT07796503
- Record updated
- 1 September 2026
- Original description
This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity. During this operation, surgeons create a bypass of part of the small intestine, and the length of this bypassed segment (called the biliopancreatic limb) affects both weight loss and the risk of nutritional side effects. In this trial, one group of patients has the limb length calculated individually based on the measured total length of their small intestine (TSBL-based method), while the other group receives a limb length based on standard body mass index (BMI) categories (BMI-based method). The study compares weight loss outcomes, improvement of obesity-related health problems, and complication rates between the two approaches over 12 months after surgery. The trial is being conducted at a single center in Almaty, Kazakhstan, and plans to enroll 100 patients total; this record reflects an interim analysis based on the first 75 patients enrolled.Read full original descriptionShow less
TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass: Interim Results of a Randomized Trial
This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity. During this operation, surgeons create a bypass of part of the small intestine, and the length of this bypassed segment (called the biliopancreatic limb) affects both weight loss and the risk of nutritional side effects. In this trial, one group of patients has the limb length calculated individually based on the measured total length of their small intestine (TSBL-based method), while the other group receives a limb length based on standard body mass index (BMI) categories (BMI-based method). The study compares weight loss outcomes, improvement of obesity-related health problems, and complication rates between the two approaches over 12 months after surgery. The trial is being conducted at a single center in Almaty, Kazakhstan, and plans to enroll 100 patients total; this record reflects an interim analysis based on the first 75 patients enrolled.
Inclusion: Age between 18 and 65 years; BMI ≥35 kg/m² in non-Asian populations or ≥32.5 kg/m² in Asian populations; Presence or absence of metabolic comorbidities (including type 2 diabetes, hypertension, and dyslipidaemia); Eligibility for primary one-anastomosis gastric bypass (OAGB); Provision of written informed consent.
Exclusion: Severe intra-abdominal adhesions due to prior surgery; Severe decompensated cardiac, pulmonary, hepatic, or renal disease; Acute inflammatory conditions; Active gastric or duodenal ulcer; Psychiatric disorders or substance abuse; Active malignancy; Secondary obesity related to hypothalamic-pituitary-adrenal axis disorders; BMI below the defined thresholds; Pregnancy or breastfeeding.