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Observing how atypical parkinsonian syndromes progress over time

Follows people with atypical parkinsonian syndromes to track how symptoms and brain scans change.

Plain-language title generated from the registry record
Registry title: Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

Key facts

Where
Changshu, Deyang, Huai'an, Huzhou, Jiaxing, Kunshan, Mianyang, Nanjing, Nantong, Suqian, Suzhou, Xuzhou, Yancheng, Yangzhou, Yantai, Zhangjiagang, and Zhenjiang, ChinaSee the 20 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with an atypical parkinsonian condition (MSA, DLB, PSP or CBD) who meet set diagnostic criteria. It only observes how the disease changes over time.

Age
18 years or older
Sex
All sexes can join
Disease stage
Probable MSA (disease duration up to 3 years), probable DLB (MMSE 18 or higher), probable PSP-Richardson syndrome (duration up to 2 years), or probable CBD with asymmetric cortical symptoms.

Main reasons for not taking part

  • Parkinson's disease
  • Spinocerebellar ataxia (SCA) and other secondary autonomic failure
  • Vascular parkinsonism
  • Parkinsonism caused by stroke or tumor
  • Parkinsonism caused by immune-mediated encephalitis

Read by machine on 13 November 2026.

Where in China

  • Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu, ChinaContact: Juping ChenTaking people
  • Deyang People's HospitalDeyang, ChinaContact: Ping ZhangNot yet recruiting
  • The Second People's Hospital of Huai'anHuai'an, ChinaContact: Xiangyang CaoNot yet recruiting
  • Changxing people' s hospitalHuzhou, ChinaContact: Donghui LiNot yet recruiting
  • Jiaxing Second HospitalJiaxing, ChinaContact: Yanping WangNot yet recruiting
  • The First People's Hospial of KunshanKunshan, ChinaContact: Qing, TangNot yet recruiting
  • Mianyang 404 HospitalMianyang, ChinaContact: Zongqin LiNot yet recruiting
  • Jiangsu Province Official HospitalNanjing, ChinaContact: Huifen ZhengNot yet recruiting
  • Affiliated Hospital of Nantong UniversityNantong, ChinaContact: Xiaosu GuNot yet recruiting
  • The Second Affiliated Hospital of Nantong UniversityNantong, ChinaContact: Jia LiNot yet recruiting
  • Jiangsu Province （Suqian）HospitalSuqian, ChinaContact: Dan LiTaking people
  • The Forth Affiliated Hospital of Soochow UniversitySuzhou, ChinaContact: Yali WangTaking people
  • The Second Affiliated Hospital of Soochow UniversitySuzhou, ChinaContact: Jinru ZhangTaking people
  • The affiliated hospital of xuzhou medical universityXuzhou, ChinaContact: Liguo DongNot yet recruiting
  • The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou, ChinaContact: Zhining LiNot yet recruiting
  • Yancheng Third People's HospitalYancheng, ChinaContact: Haihua SunTaking people
  • Affiliated Hospital of Yangzhou UniversityYangzhou, ChinaContact: Jiangbing LiuNot yet recruiting
  • Yantai Yuhuangding HospitalYantai, ChinaContact: Chao RenNot yet recruiting
  • Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine HospitalZhangjiagang, ChinaContact: Yaming SunNot yet recruiting
  • The Forth People's Hospital of ZhenjiangZhenjiang, ChinaContact: Jinjun QianTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Second Affiliated Hospital of Soochow University
Trial code
NCT07805967
Record updated
8 September 2026
Original description
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.Read full original descriptionShow less

Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

Inclusion: MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) ; DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) ; PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years ; CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).

Exclusion: Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure ; Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

ClinicalTrials.gov NCT07805967