Observing how atypical parkinsonian syndromes progress over time
Follows people with atypical parkinsonian syndromes to track how symptoms and brain scans change.
Plain-language title generated from the registry record
Registry title: Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)
Key facts
- Where
- Changshu, Deyang, Huai'an, Huzhou, Jiaxing, Kunshan, Mianyang, Nanjing, Nantong, Suqian, Suzhou, Xuzhou, Yancheng, Yangzhou, Yantai, Zhangjiagang, and Zhenjiang, ChinaSee the 20 sites
Where in China
- Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu, ChinaTaking people
- Deyang People's HospitalDeyang, ChinaNot yet recruiting
- The Second People's Hospital of Huai'anHuai'an, ChinaNot yet recruiting
- Changxing people' s hospitalHuzhou, ChinaNot yet recruiting
- Jiaxing Second HospitalJiaxing, ChinaNot yet recruiting
- The First People's Hospial of KunshanKunshan, ChinaNot yet recruiting
- Mianyang 404 HospitalMianyang, ChinaNot yet recruiting
- Jiangsu Province Official HospitalNanjing, ChinaNot yet recruiting
- Affiliated Hospital of Nantong UniversityNantong, ChinaNot yet recruiting
- The Second Affiliated Hospital of Nantong UniversityNantong, ChinaNot yet recruiting
- Jiangsu Province （Suqian）HospitalSuqian, ChinaTaking people
- The Forth Affiliated Hospital of Soochow UniversitySuzhou, ChinaTaking people
- The Second Affiliated Hospital of Soochow UniversitySuzhou, ChinaTaking people
- The affiliated hospital of xuzhou medical universityXuzhou, ChinaNot yet recruiting
- The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou, ChinaNot yet recruiting
- Yancheng Third People's HospitalYancheng, ChinaTaking people
- Affiliated Hospital of Yangzhou UniversityYangzhou, ChinaNot yet recruiting
- Yantai Yuhuangding HospitalYantai, ChinaNot yet recruiting
- Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine HospitalZhangjiagang, ChinaNot yet recruiting
- The Forth People's Hospital of ZhenjiangZhenjiang, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Second Affiliated Hospital of Soochow University
- Trial code
- NCT07805967
- Record updated
- 8 September 2026
- Original description
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.Read full original descriptionShow less
Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.
Inclusion: MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) ; DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) ; PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years ; CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).
Exclusion: Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure ; Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .