Low-intensity endurance exercise for people with lung cancer and cancer-related fatigue
Tests gentle endurance exercise for fatigue in people with lung cancer.
Key facts
- Who runs it
- Taipei Medical University
- Where
- Taipei, TaiwanSee the site
- Trial code
- Registry title
- The Effects of Low Intensity Endurance Exercise on Improving Mitochondrial Function, Cell Bioelectrical Impedance Phase Angle, Fatigue and Quality of Life in Lung Cancer Patients With Cancer-related Fatigue
- Status
- Recruiting
- People taking part
- 150 people, planned
- Started
- 10 Mar 2025
- Expected to end
- 31 Jul 2027
- Type of study
- Interventional, 3 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Low-Intensity Endurance Continuous Exercise
- Low-Intensity Endurance Interval Exercise
- Record updated
- 8 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with lung cancer who have cancer-related fatigue and whose doctor says they can exercise safely. It tests low-intensity endurance exercise.
- Age
- 20 to 70 years
- Sex
- All sexes can join.
- Disease stage
- Lung cancer diagnosed by a physician, with cancer-related fatigue. No stage is named in the record.
Main reasons for not taking part
- Cannot communicate in Mandarin, Taiwanese, or Hakka
- A physician finds them physically unable to do any exercise
- Has not finished elementary school
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Patients who are diagnosed with lung cancer by a physician
- Patients aged 20-70 years
- Patients who are determined by a physician, after assessment of their physical condition, to be suitable for exercise
- Patients who have graduated from elementary school or above
Who cannot take part
- Patients who are unable to communicate in Mandarin, Taiwanese, or Hakka
- Patients who are determined by a physician to be physically unsuitable for performing any exercise
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 70 years old?
Where in Taiwan
- Taipei Medical UniversityTaipei, TaiwanContact: Hsiu Ting Tsai, PhDTaking people
About the trial
What the trial wants to find out
To conduct a randomized controlled trial (RCT) targeting lung cancer patients with cancer-related fatigue to achieve the following objectives:
Read full original descriptionShow less
Objective 1: To investigate whether a low-intensity endurance exercise intervention can effectively improve mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, cellular bioelectrical impedance phase angle, cancer-related fatigue, and quality of life in lung cancer patients with cancer-related fatigue.
Objective 2: To explore whether the low-intensity endurance exercise intervention improves cancer-related fatigue and quality of life in lung cancer patients through direct or indirect effects by modulating mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, and cellular bioelectrical impedance phase angle.
The 3 groups in the trial
- Control GroupNo study treatment, for comparison
No exercise intervention will be implemented, and participants will carry out their daily activities according to their previous lifestyle habits.
- Continuous Training GroupTreatment being tested
Level 2 low-intensity continuous endurance exercise: Participants will perform Level 2 low-intensity endurance exercise training continuously for at least 30 minutes per day, at least 5 days per week, for 12 consecutive weeks. The exercise intensity will be 75-80% of peak heart rate, with a rating of perceived exertion of 11-12. At this intensity, participants will perceive the exercise as easy, but their breathing sound will increase; they will be able to converse comfortably during exercise but may occasionally need to pause for breath
Treatment: Low-Intensity Endurance Continuous Exercise
- Intermittent Training GroupTreatment being tested
Participants will perform alternating training consisting of 3 minutes of Level 2 low-intensity endurance exercise and 3 minutes of Level 1 minimal-intensity endurance exercise, for a total of 5 alternating cycles. The training will be performed continuously for at least 30 minutes per day, at least 5 days per week, for 12 consecutive weeks. Level 1 exercise intensity will be 65-75% of peak heart rate, with a rating of perceived exertion below 11, indicating that participants perceive the exercise as very easy.
Treatment: Low-Intensity Endurance Interval Exercise
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effects of Low Intensity Endurance Exercise on Improving Mitochondrial Function, Cell Bioelectrical Impedance Phase Angle, Fatigue and Quality of Life in Lung Cancer Patients With Cancer-related Fatigue
- Plain-language title
- Low-intensity endurance exercise for people with lung cancer and cancer-related fatigueGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Fit questions
- Built from NCT07806682, who can take part
- Record updated
- 8 September 2026