Olive oil drink before lung cancer surgery to test for chylothorax
Tests olive oil drunk before surgery in adults with resectable lung cancer.
Key facts
- Who runs it
- Fudan University
- Where
- Shanghai, ChinaSee the site
- Trial code
- Registry title
- Olive Oil Before Lung Cancer Surgery to Prevent Chylothorax
- Status
- Recruiting
- People taking part
- 1,036 people, planned
- Started
- 15 Mar 2026
- Expected to end
- 30 Dec 2030
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Extra-Virgin Olive Oil
- Record updated
- 8 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with lung cancer that can be removed by surgery. Half will drink 40 mL of olive oil before surgery, to see if it lowers the chance of chylothorax.
- Age
- 18 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Lung cancer that can be removed by surgery. ECOG performance status of 0 or 1.
- Earlier treatment
- No earlier surgery for lung cancer. No earlier radiotherapy or chemotherapy.
Main reasons for not taking part
- Allergy to olive oil or any of its components
- History of acute or chronic pancreatitis or severe biliary disease
- Fat malabsorption syndrome
- Earlier chest surgery, chest radiotherapy or chemotherapy on the same side
- Unable to follow the dietary instructions before surgery
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Voluntary participation and willing and able to complete all study procedures
- Age 18 to 80 years, inclusive, at informed consent
- Eastern Cooperative Oncology Group performance status of 0 or 1
- Resectable lung cancer
- No prior surgery for lung cancer
- Treatment-naive and no prior radiotherapy or chemotherapy
- Able to take food orally before surgery
Who cannot take part
- Prior ipsilateral thoracic surgery or thoracic radiotherapy or chemotherapy
- Allergy to olive oil or any of its components
- History of acute or chronic pancreatitis or severe biliary disease
- Fat malabsorption syndrome
- Unable to comply with preoperative dietary instructions
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in China
- Fudan University Shanghai Cancer CenterShanghai, ChinaContact: Yang Zhang, MDTaking people
About the trial
What the trial wants to find out
Chylothorax is a rare but serious complication after lung cancer surgery and mediastinal lymph node dissection. This multicenter randomized trial will evaluate whether drinking 40 mL of extra-virgin olive oil 4 hours before surgery can reduce the occurrence of chylothorax after curative lung cancer resection. A total of 1,036 adults with resectable lung cancer will be assigned in a 1:1 ratio to preoperative oral olive oil or standard preoperative fasting without additional olive oil. The primary outcome is the occurrence of chylothorax within 30 days after surgery. Secondary outcomes include repeat surgery, postoperative complications, chest drainage, length of chest tube use, length of hospital stay, and the safety and tolerability of the intervention.
The 2 groups in the trial
- Preoperative Olive OilTreatment being tested
Participants drink 40 mL of extra-virgin olive oil 4 hours before surgery and then continue fasting from food and water until surgery.
Treatment: Extra-Virgin Olive Oil
- Standard Preoperative FastingNo study treatment, for comparison
Participants follow each center's standard preoperative fasting regimen: no food for 8 hours and no water for 2 hours before surgery. No additional olive oil is given.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Multicenter, Prospective, Randomized Controlled Trial of Preoperative Oral Olive Oil for the Prevention of Postoperative Chylothorax in Patients With Lung Cancer
- Plain-language title
- Olive oil drink before lung cancer surgery to test for chylothoraxGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Fit questions
- Built from NCT07807696, who can take part
- Record updated
- 8 September 2026