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Bone Marrow Injection in Fracture of Femoral Neck

Key facts

Who runs it
Yaser Alkanash
Where
Syria1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
32 people, planned
Started
12 May 2025
Expected to end
1 Aug 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Anatomical reduction and fixation with bone marrow injection
  • Anatomical reduction with Fixation
Record updated
8 September 2026

Who can take part

Age
18 years to 55 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

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Who can take part

  • Age between 18 and 55 years
  • Intracapsular femoral neck fracture classified as Garden type III or IV
  • The time elapsed since the fracture occurred must not exceed 24 hours

Who cannot take part

  • Neglected femoral neck fractures or fractures that occurred more than 24 hours prior to presentation
  • Age under 18 years or over 55 years
  • Open femoral neck fracture
  • Polytrauma patients who are in shock or admitted to the intensive care unit (ICU)

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 55 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Objectives:

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* Primary objective : * To investigate the predisposing factors for femoral neck fractures, including age, sex, and associated comorbidities. * To investigate the complications associated with intracapsular femoral neck fractures, particularly in young patients. * To evaluate the effectiveness of autologous bone marrow injection at the femoral neck fracture site and its effect on: * Achieving complete fracture union. * Reducing the time required for fracture healing. * Reducing the incidence of avascular necrosis of the femoral head. * Secondary objective:

The study addresses the challenge of performing total hip arthroplasty in young patients. Complications following intracapsular femoral neck fractures, particularly avascular necrosis and nonunion, may ultimately necessitate this treatment option. However, total hip arthroplasty is generally less desirable in young patients because of:

* Early prosthetic loosening. * The potential need for revision arthroplasty later in life due to wear and deterioration of prosthetic components over time. * Higher complication rates and lower long-term success rates. In this study, we will focus on the use of fully threaded cannulated screws combined with bone marrow injection into the fracture site, and evaluate their effect on the healing and union of intracapsular femoral neck fractures.

The 2 groups in the trial

  • Group A:fixation using three fully threaded cancellousExisting treatment, for comparison

    Patients will undergo surgical intervention on the fractured hip under appropriate anesthesia. Anatomical reduction of the fracture will be achieved under fluoroscopic guidance, followed by fixation through a lateral surgical approach to the hip using three fully threaded cancellous screws.

    Treatment: Anatomical reduction with Fixation

  • Group B: Fixation using three fully cancellous screws with injection of autologous bone marrowTreatment being tested

    Patients will undergo the same surgical procedure under appropriate anesthesia, with anatomical reduction of the fracture achieved under fluoroscopic guidance. The fracture will then be fixed through a lateral surgical approach using three fully threaded cancellous screws, in addition to the following procedure After drilling through the lateral femoral cortex toward the fracture line and advancing to the femoral head up to the subchondral bone, approximately 1-1.5 cm below the articular surface of the femoral head, 15 mL of autologous bone marrow will be aspirated from the iliac crest, approximately 1 cm posterior to the anterior superior iliac spine (ASIS), after ensuring that the site is included within the surgical field. The aspirate will be distributed into three heparin-prepared tubes. The harvested autologous bone marrow will then be injected through the prepared screw channels to ensure delivery of the graft to the fracture site. The screws will subsequently be inserted.

    Treatment: Anatomical reduction and fixation with bone marrow injection

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Outcome of Bone Marrow Injection at Fracture Site in Intracapsular Fracture of Femoral Neck Treated by Head Preserving Surgery
Fit questions
Built from NCT07808294, who can take part
Record updated
8 September 2026