Using ultrasound to classify liver involvement in advanced or recurrent ovarian cancer
Tests ultrasound for classifying liver involvement in women with advanced or recurrent ovarian cancer.
Plain-language title generated from the registry record
Registry title: HERCULES: Ultrasound-Based Liver Involvement Classification in Ovarian Cancer
Key facts
- Where
- Roma, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women with advanced or recurrent ovarian, fallopian tube, or primary peritoneal cancer who are having complete cytoreductive surgery. It tests an ultrasound method to check the liver area before surgery.
- Age
- 18 years or older
- Sex
- Women only
- Disease stage
- Suspected or confirmed epithelial ovarian, fallopian tube, or primary peritoneal cancer. Suspected primary FIGO stage III-IV disease, or recurrent ovarian cancer, going to complete cytoreductive surgery.
- Earlier treatment
- No earlier radiotherapy to the liver area.
Main reasons for not taking part
- Earlier radiotherapy involving the liver area
Read by machine on 13 November 2026.
Where in Italy
- Fondazione Policlinico Universitario Agostino Gemelli IRCCSRoma, ItalyContact: Antonia Carla TestaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Trial code
- NCT07808320
- Record updated
- 8 September 2026
- Original description
This monocentric observational pilot study aims to assess the feasibility of a standardized two-dimensional ultrasound (2D US) approach for the preoperative assessment and anatomo-surgical classification of liver-area involvement in women with advanced or recurrent epithelial ovarian cancer. The study will evaluate whether standardized ultrasound acquisition and reporting can identify the main patterns of liver-area disease and assign them to predefined surgical classes. In patients with parenchymal lesions, the study will also explore the ability of ultrasound to differentiate liver peritoneal infiltration from hematogenous hepatic metastases. Clinical, ultrasound, surgical, and histological data will be collected from a retrospective and prospective cohort. Ultrasound findings will be compared with surgical findings, with histology used as an additional reference standard when available. The study will also develop a standardized ultrasound acquisition protocol and reporting template to improve reproducibility and support preoperative surgical planning.Read full original descriptionShow less
Ultrasound-based Anatomo-Surgical Classification of Liver-Area Involvement in Ovarian Cancer (HERCULES Study): A Feasibility and Methodology Study
This monocentric observational pilot study aims to assess the feasibility of a standardized two-dimensional ultrasound (2D US) approach for the preoperative assessment and anatomo-surgical classification of liver-area involvement in women with advanced or recurrent epithelial ovarian cancer. The study will evaluate whether standardized ultrasound acquisition and reporting can identify the main patterns of liver-area disease and assign them to predefined surgical classes. In patients with parenchymal lesions, the study will also explore the ability of ultrasound to differentiate liver peritoneal infiltration from hematogenous hepatic metastases. Clinical, ultrasound, surgical, and histological data will be collected from a retrospective and prospective cohort. Ultrasound findings will be compared with surgical findings, with histology used as an additional reference standard when available. The study will also develop a standardized ultrasound acquisition protocol and reporting template to improve reproducibility and support preoperative surgical planning.
Inclusion: Women aged ≥18 years; Suspicious or histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma; Suspicious primary FIGO stage III-IV disease or recurrent ovarian cancer undergoing complete cytoreductive surgery; For participants included in the prospective cohort, written informed consent for study participation and processing of personal data; For the retrospective cohort, eligible participants may include individuals for whom informed consent cannot be obtained because they are deceased or cannot be contacted despite all reasonable efforts to trace them. Data processing will be conducted in accordance with applicable Italian data protection regulations.
Exclusion: Previous radiotherapy involving the hepatic area.