Tailored acupuncture and lifestyle changes for insulin resistance in polycystic ovary syndrome
Compares tailored acupuncture with lifestyle support against standard care in women with polycystic ovary syndrome.
Plain-language title generated from the registry record
Registry title: Multimodal Ocular Diagnosis-Guided Precision Acupuncture and Lifestyle Intervention for PCOS
Key facts
- Where
- Beijing, ChinaSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women with polycystic ovary syndrome (PCOS) and a higher body weight. It tests acupuncture plus lifestyle changes to improve insulin resistance.
- Age
- 18 to 40 years
- Sex
- Women only
- Disease stage
- PCOS diagnosed by the 2003 Rotterdam criteria: at least two of three signs (rare or no ovulation, high male hormones, polycystic ovaries on ultrasound). Body mass index (BMI) of 25-40 kg/m².
- Earlier treatment
- Cannot have used certain medicines in the past 3 months (for example steroids, insulin, glucose-lowering drugs, antidepressants, hormonal contraceptives, ovulation drugs). Cannot have had continuous acupuncture for at least 2 months before the trial.
Main reasons for not taking part
- High male hormones from other causes (for example prolactin or thyroid problems)
- Kidney disease, liver problems, autoimmune disease or cancer
- Type 1 diabetes or HbA1c above 53 mmol/mol (7%)
- Pregnant, breastfeeding, pregnant in the past 6 months, or planning pregnancy
- Daily smoking or alcohol use
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT07809503, who can take part
Where in China
- Beijing Haidian HospitalBeijing, ChinaContact: Haolin Zhang, PhDNot yet recruiting
- Peking University Third HospitalBeijing, ChinaContact: Haolin Zhang, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Peking University Third Hospital
- Trial code
- NCT07809503
- Record updated
- 9 September 2026
- Original description
This study is designed as a prospective, multicenter, parallel-group randomized controlled trial to evaluate the effectiveness of a "precision acupuncture + personalized lifestyle" intervention, guided by dynamic multimodal risk monitoring based on the four diagnostic methods of Traditional Chinese Medicine (TCM), in improving insulin resistance in patients with polycystic ovary syndrome (PCOS). Compared with "conventional acupuncture + standard lifestyle intervention," the study will primarily assess changes in the homeostatic model assessment of insulin resistance (HOMA-IR) after 12 weeks of treatment. The safety of the intervention, improvements in endocrine and metabolic profiles, menstrual and ovulatory outcomes, psychological status, quality of life, and health-economic outcomes will also be evaluated. The study aims to provide evidence for establishing an intelligent and individualized clinical management model for PCOS.Read full original descriptionShow less
MulticenterClinical Study of Intelligent and Precise Acupuncture and Lifestyle Interventions for Polycystic Ovary Syndrome Guided by Multimodal With Ocular Diagnosis
This study is designed as a prospective, multicenter, parallel-group randomized controlled trial to evaluate the effectiveness of a "precision acupuncture + personalized lifestyle" intervention, guided by dynamic multimodal risk monitoring based on the four diagnostic methods of Traditional Chinese Medicine (TCM), in improving insulin resistance in patients with polycystic ovary syndrome (PCOS). Compared with "conventional acupuncture + standard lifestyle intervention," the study will primarily assess changes in the homeostatic model assessment of insulin resistance (HOMA-IR) after 12 weeks of treatment. The safety of the intervention, improvements in endocrine and metabolic profiles, menstrual and ovulatory outcomes, psychological status, quality of life, and health-economic outcomes will also be evaluated. The study aims to provide evidence for establishing an intelligent and individualized clinical management model for PCOS.
Inclusion: Aged18-40 years, inclusive; Body mass index (BMI) of 25-40 kg/m², inclusive; Meeting the 2003 Rotterdam diagnostic criteria for polycystic ovary syndrome (PCOS), defined by the presence of at least two of the following three criteria: Oligo-ovulation or anovulation; Clinical and/or biochemical signs of hyperandrogenism; Polycystic ovarian morphology on ultrasonography; Willing to participate voluntarily in the study, able to understand the study procedures, and able to provide written informed consent.
Exclusion: Having received continuous acupuncture treatment for at least 2 months prior to study treatment; Presence of hyperandrogenemia due to other causes, such as hyperprolactinemia, thyroid disorders, congenital adrenal hyperplasia, or exogenous androgen use; Presence of language barriers, psychiatric disorders, or other conditions that may impair the participant's ability to understand the study, comply with the intervention, or complete follow-up assessments; Presence of renal disease (creatinine clearance <60 mL/min), hepatic impairment, autoimmune disease, or malignancy; Type 1 diabetes mellitus or glycated hemoglobin (HbA1c) >53 mmol/mol (7%). - Use, within the past 3 months, of medications that may affect study assessments, including glucocorticoids, insulin, glucose-lowering agents such as acarbose, antidepressants, hormonal contraceptives, ovulation-inducing agents, or other relevant medications; Blood pressure >160/100 mmHg; Currently pregnant or breastfeeding, pregnancy within the past 6 months, or planning to become pregnant during the study period; Daily smoking or alcohol consumption.