Aloe vera mouthwash to prevent mouth sores in adults with blood cancers
Tests aloe vera mouthwash against usual care for mouth sores in adults with leukemia.
Plain-language title generated from the registry record
Registry title: Prevention of Oral Mucositis in Adults in With Hematologic Malignancy
Key facts
- Where
- Milwaukee, Oak Lawn, and Park Ridge, United StatesSee the 3 sites
Where in United States
- Aurora St. Luke's Medical CenterMilwaukee, United StatesNo longer taking part
- Advocate Christ Medical CenterOak Lawn, United StatesNo longer taking part
- Advocate Lutheran GeneralPark Ridge, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University Health Sciences
- Trial code
- NCT07809984
- Record updated
- 22 October 2026
- Original description
The goal of this quasiexperimental cohort controlled intervention study is to learn if aloe vera mouthwash works better than usual care in the prevention and treatment of oral mucositis. Researchers will compare aloe vera to usual care. Participants in the intervention group will rinse their mouths with aloe vera 4 x/day for 28 days of their treatment. They will also complete questionnaires about oral health and mucositis.Read full original descriptionShow less
Impact of Aloe Vera Mouthwash on the Prevention and Severity of Oral Mucositis in Adults in With Hematologic Malignancies
The goal of this quasiexperimental cohort controlled intervention study is to learn if aloe vera mouthwash works better than usual care in the prevention and treatment of oral mucositis. Researchers will compare aloe vera to usual care. Participants in the intervention group will rinse their mouths with aloe vera 4 x/day for 28 days of their treatment. They will also complete questionnaires about oral health and mucositis.
Inclusion: Medical diagnosis of acute leukemia and receiving high or low intensity chemotherapy; English speaking/reading (without an interpreter); Access to a personal email address to support study participation.
Exclusion: Transplant patients; Patients receiving end of life/hospice care; Allergy to Aloe Vera; Cognitively impaired or have a psychiatric condition that would prevent ability to provide informed consent; Patients with an active eating disorder; Patients with preexisting mucositis; Pregnant women.