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Physical Activity, Sedentary Behavior and Artery Health in Adolescents With Obesity

Studies whether activity and sitting habits relate to artery thickness in adolescents with obesity.

Key facts

Who runs it
University of Avignon
Where
Palavas-les-Flots, FranceSee the site
Trial code
Registry title
Associations Between Physical Activity and Sedentary Behavior Profiles and Carotid Intima-media Thickness in Adolescents With Obesity
Status
Recruiting
People taking part
108 people, planned
Started
9 Sept 2024
Expected to end
Sept 2027
Type of study
Observational
Record updated
9 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adolescents aged 11 to 18 who live with obesity. It studies how activity and sitting habits relate to artery wall thickness.

Age
11 to 18 years
Sex
All sexes
Disease stage
Obesity, shown by a BMI Z-score in the obesity range (Rolland-Cachera et al., 1991 growth charts)

Main reasons for not taking part

  • A joint, heart or other reason that makes physical activity unsafe
  • Taking part in another study
  • Being in an exclusion period from a previous study
  • Parent or guardian or adolescent refuses to sign the consent or assent form
  • Health insurance coverage is missing

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • The parent(s) or legal guardian(s) must have provided parental consent, and the adolescent must have provided their assent
  • The adolescent must be affiliated with or covered by a health insurance scheme
  • The adolescent must be aged between 11 and 18 years
  • The participant must have a Body Mass Index (BMI) Z-score corresponding to obesity (reference: Rolland-Cachera et al., 1991 growth charts)

Who cannot take part

  • The adolescent is within an exclusion period determined by a previous study
  • The adolescent has a contraindication to physical activity (joint, cardiac, or other)
  • The adolescent is participating in another study
  • The parent(s) or legal guardian(s) or the adolescent refuses to sign the parental consent or assent form, respectively
  • It is not possible to provide the adolescent or the parent(s) or legal guardian(s) with the required information for informed consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 11 and 18 years old?

Where in France

  • Institut Saint PierrePalavas-les-Flots, FranceContact: Delphine MassonTaking people

About the trial

What the trial wants to find out

Physical activity behaviors are key and modifiable factors of cardiovascular health from childhood. They encompass both physical activity, defined as any bodily movement produced by skeletal muscles that results in energy expenditure, and sedentary behavior, characterized by low energy expenditure while awake. Studying these behaviors in their diversity, beyond a simple active-inactive opposition, allows for a better understanding of their effects on health.

Read full original descriptionShow less

In adolescents, high levels of sedentary behavior and low levels of physical activity are both associated with an increased risk of overweight or obesity. Current recommendations advocate for at least 60 minutes of moderate-to-vigorous physical activity per day and the reduction of sedentary time. However, more than 80% of French adolescents do not meet these recommendations, a trend that is even more pronounced and problematic among those living with obesity.

Pediatric obesity is associated with early alterations in vascular health. Carotid intima-media thickness (cIMT), measured by ultrasound, is a recognized biomarker of future cardiovascular risk. Several studies have shown that sustained physical activity is associated with lower cIMT and better endothelial function, independently of body size. However, the methodological limitations of current studies, and the lack of data specific to adolescents with obesity, highlight the need for further research.

This project aims to better understand, in adolescents with obesity, the associations between physical activity and sedentary behavior profiles and physical fitness, on the one hand, and structural parameters, particularly cIMT, and vascular functional parameters known for their value as subclinical biomarkers of cardiovascular risk, on the other hand.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Associations Between Physical Activity and Sedentary Behavior Profiles and Carotid Intima-media Thickness in Adolescents With Obesity
Plain-language title
Physical Activity, Sedentary Behavior and Artery Health in Adolescents With ObesityGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07811115, who can take part
Record updated
9 September 2026