Preventive Treatment for Latent Tuberculosis Infection in Chinese High School and College Freshmen
Tests short preventive treatment against active tuberculosis in freshmen with latent tuberculosis infection.
Plain-language title generated from the registry record
Registry title: Latent Infection Freshmen Tracking for Tuberculosis
Key facts
- Where
- Meishan and Nantong, ChinaSee the 2 sites
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 24 years old?
Source: NCT07811518, who can take part
Where in China
- Meishan Municipal Center for Disease Prevention and ControlMeishan, ChinaTaking people
- Affiliated Hospital of Nantong UniversityNantong, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Affiliated Hospital of Nantong University
- Trial code
- NCT07811518
- Record updated
- 10 September 2026
- Original description
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing active TB over a 3-to-4-years period.Read full original descriptionShow less
Real-World Implementation and Effectiveness of Tuberculosis Preventive Treatment in School Health Services in China
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing active TB over a 3-to-4-years period.
Main question: Does taking short-course preventive treatment reduce the risk of active TB in freshmen who have strong positive TB skin tests?
All freshmen across 26 schools in Meishan City, Sichuan Province, China were screened for TB. Among them, the students with strong positive skin tests (indicating latent TB infection) and no active disease entered the study. Students voluntarily chose to either take a 3-month short-course preventive treatment under campus medical supervision or receive routine health observation without medication. Researchers tracked all participants for 3 to 4 years to monitor who developed active TB and evaluate the treatment's safety and effectiveness.
Inclusion: Matriculating freshmen aged 14-24 years enrolled across 26 participating educational institutions; Completion of baseline tuberculosis screening, including systematic symptom screening, digital chest radiography, and tuberculin skin test (TST); Target cohort requirement: TST strong reactivity (induration ≥15 mm or severe local reactions such as blisters, necrosis, or lymphangitis) with active TB ruled out at baseline; Control cohort requirement: TST induration <15 mm (including negative <5 mm, weakly positive 5-9 mm, and moderately positive 10-14 mm).
Exclusion: Presence of active TB at baseline screening; Voluntary receipt of Vaccae vaccination (for the target cohort).