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Microwave heat treatment guided by endoscopic ultrasound for advanced pancreatic or liver cancer

Tests a microwave device that heats tumors, in adults with advanced pancreatic or liver cancer.

Key facts

Who runs it
Banner Health
Where
Chicago, Gilbert, Houston, Knoxville, Los Angeles, and Morgantown, United StatesSee the 6 sites
Trial code
Registry title
CREO - Microwave Ablation Feasibility Study
Status
Recruiting
People taking part
75 people, planned
Started
19 Feb 2026
Expected to end
Aug 2028
Type of study
Interventional
Treatments tested
  • EUS-Guided MWA Device
Record updated
6 November 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with advanced pancreatic or liver cancer that cannot be removed by surgery or has spread. It tests a heat-based tumor treatment given through an ultrasound-guided endoscope.

Age
18 years or older
Sex
Men and women
Disease stage
Locally advanced, unresectable or metastatic cancer (Stage III or IV), confirmed by tissue tests. At least 1 tumor must be reachable through the stomach wall, such as in the pancreas or liver, and be at least 1 cm (0.4 in) across.
Earlier treatment
People who are in another trial with local ablation or other local treatment that could affect the same organ or tumor cannot join.

Main reasons for not taking part

  • Pancreatic cancer where upfront surgery to remove the tumor is possible
  • Taking part in another trial with local ablation or other local treatment affecting the target organ or tumor
  • Any condition that the investigator thinks could add risk to safety or well-being

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Male or female ≥18 years of age
  • Willing and able to provide written informed consent
  • Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV)
  • At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc)
  • The tumor(s) must be ≥1 cm in diameter

Who cannot take part

  • Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study
  • Participant is a candidate for upfront resection of pancreatic cancer
  • Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being

Where in United States

  • Rush University Medical CenterChicago, United StatesContact: Amanda LinNot yet recruiting
  • Banner MD Anderson Cancer Center and Gateway HospitalGilbert, United StatesContact: Neil Sharma, MDTaking people
  • Memorial Hermann Texas Medical CenterHouston, United StatesContact: Cecelia LaraNot yet recruiting
  • University of Tennessee MedicalKnoxville, United StatesContact: Brandy HerbertNot yet recruiting
  • Cedars SinaiLos Angeles, United StatesContact: Sara KaramehNot yet recruiting
  • West Virginia University MedicineMorgantown, United StatesContact: Chad GlazeNot yet recruiting

About the trial

What the trial wants to find out

The goal of this study is to assess the overall success of energy delivery during treatment using the ultrasound guided microwave ablation device in patients with locally advanced, unresectable, or metastatic cancer. Secondly, this study aims to explore the procedural/clinical safety of treatment with the device and the antitumor effect following treatment with the device.

The group in the trial

  • Endoscopic Ultrasound (EUS) - Guided Microwave Ablation (MWA) Device GroupOther group

    This is a open label feasibility study and only eligible participants will be enrolled into the single arm of the study to receive MWA with this specific device.

    Treatment: EUS-Guided MWA Device

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Investigator-Initiated Feasibility Study of a Novel Endoscopic Ultrasound Guided Microwave Ablation Device in Patients With Locally Advanced, Unresectable, or Metastatic Cancer
Plain-language title
Microwave heat treatment guided by endoscopic ultrasound for advanced pancreatic or liver cancerGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 13 November 2026.
Record updated
6 November 2026