Heated Salt Water During Bladder Tumor Surgery for Early-Stage Bladder Cancer
Tests whether warmed saline during surgery is safe in people with non-muscle invasive bladder cancer.
Plain-language title generated from the registry record
Registry title: Feasibility of HISA During TURBT for NMIBC
Key facts
- Where
- Charleston, United StatesSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a small bladder tumor that has not grown into the bladder muscle and is having the tumor removed through the urethra. Heated or room temperature saline is used during the surgery.
- Age
- 18 to 89 years
- Sex
- Women and men can join.
- Disease stage
- A visible papillary bladder tumor of 3 cm (1.2 in) or less, planned for removal through the urethra (TURBT). Low- to intermediate-risk non-muscle invasive bladder cancer.
Main reasons for not taking part
- Pregnant women and prisoners
- Spread of the cancer to distant parts of the body
- High-risk bladder cancer confirmed under the microscope, or earlier carcinoma in situ
- Active urinary tract infection, or a weakened immune system
- Hole in the bladder wall during the surgery
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 89 years old?
Source: NCT07817173, who can take part
Where in United States
- Charleston Area Medical Center Memorial HospitalCharleston, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- CAMC Health System
- Trial code
- NCT07817173
- Record updated
- 14 September 2026
- Original description
The goal of this prospective pilot study is to evaluate the safety and feasibility of using heated saline during bladder tumor surgery in patients with non-muscle invasive bladder cancer.Read full original descriptionShow less
A Pilot Study Using Hyperthermic Irrigation Followed by Intravesical Chemotherapy in Patients With Low- to Intermediate-Risk Non-Muscle Invasive Bladder Cancer
The goal of this prospective pilot study is to evaluate the safety and feasibility of using heated saline during bladder tumor surgery in patients with non-muscle invasive bladder cancer.
The main questions it aims to answer are:
Can heated saline be given during bladder tumor removal surgery safely?
Does using heated saline keep the bladder tumor from coming back?
Researchers will compare the heated saline to room temperature saline to see if the heated saline works to prevent the bladder tumor from coming back.
Participants will:
* Have heated saline or room temperature saline during bladder tumor surgery * Visit the clinic at 2 weeks, 3 and 6 months after bladder tumor surgery * Complete questionnaires about quality of their life and symptoms before and after surgery * Provide urine samples to test your urine at each visit before and after surgery * To have a cystoscopy to check your bladder for tumors
Inclusion: Male or female patients; Age from 18 to 89 years old; Visual diagnosis of a papillary tumor(s) ≤ 3 cm; Transurethral resection of bladder tumor (TURBT); Eastern Cooperative Oncology Group (ECOG) performance status grade 0-2; Glomerular filtration rate (GFR) ≥ 30 mL/min.
Exclusion: Patients with histologically confirmed high-risk NMIBC prior to and after TURBT; Patients with prior carcinoma is situ diagnosis; Immunosuppression defined as a patient with leukopenia or taking any active immunosuppressive medication; Patients with an active infection defined as documented urinary tract infection based on preoperative urine analysis or urine culture; Patients that had an intraoperative perforation during TURBT; Patients participating in another clinical trial with this urologic cancer diagnosis; Postoperative bladder instillation failure defined as the inability to deliver and maintain the planned volume of instilled fluid within the bladder for at least 30 minutes; Ages less than 18 years of age; Pregnant women; Prisoners; Patients with evidence of distant metastasis.