Can a new heart scan find risky plaque that predicts future heart events?
Follows adults with coronary artery disease to see if scan-found plaque predicts heart problems.
Plain-language title generated from the registry record
Registry title: PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are already scheduled for a planned (non-emergency) invasive coronary angiography. It studies whether high-risk heart artery plaques seen on a special CT scan predict future heart events.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- People scheduled for clinically indicated, non-emergency invasive coronary angiography
- Earlier treatment
- A previously implanted stent in the target vessel is a reason not to join
Main reasons for not taking part
- Kidney function eGFR below 45 mL/min/1.73 m²
- Known allergy to iodinated contrast media
- Pregnancy or breastfeeding
- Persistent atrial fibrillation or other arrhythmia that prevents good CT images
- Body mass index above 40 kg/m²
Read by machine on 12 November 2026.
Where in China
- Beijing Chaoyang Hospital，Capital Medical University, BeijingBeijing, ChinaContact: Bin Tu, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Beijing Chao Yang Hospital
- Trial code
- NCT07822737
- Record updated
- 16 September 2026
- Original description
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE). Participants will be followed for MACE and revascularization. The primary hypothesis is that the incidence of MACE is significantly higher in patients with PCCT-defined high-risk plaque than in those without. Additionally, patients will undergo Optical Coherence Tomography (OCT) and angiography within a month after PCCT; PCCT results will be compared with OCT in a cross-sectional analysis, and diagnostic performance will be evaluated against follow-up data.Read full original descriptionShow less
Prognostic Value of Photon-Counting Detector CT-Derived High-Risk Coronary Plaque Features for Predicting Major Adverse Cardiovascular Events: a Prospective Cohort Study
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE). Participants will be followed for MACE and revascularization. The primary hypothesis is that the incidence of MACE is significantly higher in patients with PCCT-defined high-risk plaque than in those without. Additionally, patients will undergo Optical Coherence Tomography (OCT) and angiography within a month after PCCT; PCCT results will be compared with OCT in a cross-sectional analysis, and diagnostic performance will be evaluated against follow-up data.
Inclusion: Age ≥18 years; Scheduled for clinically indicated, non-emergent invasive coronary angiography; Provision of written informed consent and willingness to comply with long-term follow-up.
Exclusion: Target vessel with a previously implanted stent; Known allergy to iodinated contrast media; Persistent atrial fibrillation or other arrhythmia precluding adequate ECG-gated CT acquisition; Life expectancy <2 years or any condition that, in the opinion of the investigator, makes follow-up unlikely or participation inappropriate; Estimated glomerular filtration rate <45 mL/min/1.73 m²; Pregnancy or breastfeeding; Body mass index >40 kg/m².