Ear nerve stimulation for nerve pain in older adults living with HIV
Tests gentle ear stimulation for nerve pain in older people with HIV.
Plain-language title generated from the registry record
Registry title: Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
Key facts
- Where
- Miami, United StatesSee the site
Where in United States
- Christine E Lynn Rehabilitation CenterMiami, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Miami
- Trial code
- NCT07822932
- Record updated
- 6 October 2026
- Original description
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.Read full original descriptionShow less
Mechanistic Modulation of HIV-Associated Peripheral Neuropathy in Older Adults Via Auricular Vagus Nerve Stimulation
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.
Inclusion: Established HIV infection; Glove/stocking dysesthesias lasting for ≥3 months; HIV-associated peripheral neuropathy (HIV-PN) related symptoms ≥4 (on a scale of 0-10) within the last week; Stable medical care (i.e., no changes in Antiretroviral Therapy or pain medication within 2 months of enrollment); Able to read the consent form, demonstrate understanding of study procedures and requirements, and independently provide written informed consent.
Exclusion: Implanted electronic or magnetic devices (e.g., pacemaker, cochlear implants, medication pumps, and other implanted neurostimulation systems); Recent ear trauma or metal implants in the head; History of epilepsy, unprovoked seizure, stroke, brain tumor, significant traumatic brain injury, prior intracranial surgery, or other neurological condition associated with increased seizure risk; Ferromagnetic or non-MRI-compatible metal in the head, neck, eye, or cranial region, including aneurysm clips, retained metal fragments, bullets, shrapnel, or other metallic implants not demonstrated to be TMS-compatible; Unstable cardiac disease; Head or neck cancer or metastases; Active or uncontrolled comorbidities that independently cause neuropathy (e.g., recent chemotherapy, uncontrolled diabetes with documented neuropathic complications); Clinical evidence of non-HIV neuropathy (e.g., neuropathic symptoms predating HIV diagnosis, uncontrolled diabetes); Known allergy to tape/adhesive; Pregnancy or actively breast feeding.