The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise-induced Muscular Pain
Key facts
- Who runs it
- The Hong Kong Polytechnic University
- Where
- Hong Kong1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 80 people, planned
- Started
- 26 Aug 2026
- Expected to end
- 31 Aug 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- Eccentric exercise
- Record updated
- 25 September 2026
Who can take part
- Age
- 18 years to 60 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Adults aged 18 to 60 years
- Right hand and foot dominant
Who cannot take part
- Previous major injuries or surgery involving the lower limbs
- History of any chronic musculoskeletal pain or presence of existing pain during recruitment
- Sleep disorders other than insomnia
- Clinically diagnosed psychiatric disorders
- Contraindications to vigorous exercise identified through the physical activity readiness questionnaire (PAR-Q)
- Work night shifts or rotating shift schedules
- Pregnant
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Sleep is a critical determinant of physiological recovery and pain regulation. Growing evidence suggests that sleep disruption directly heightens central and peripheral pain sensitivity to sensory stimuli (e.g., mechanical pressure, thermal stimuli), serving as a significant risk factor for the onset and persistence of musculoskeletal pain. However, the precise mechanisms through which sleep quality regulates bodily sensory sensitivity and influences the onset, progression, and recovery trajectories of acute musculoskeletal pain in the general public remain insufficiently understood.
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This study aims to investigate the relationship between sleep condition, pain sensitivity, and musculoskeletal pain dynamics in healthy adults from the general population, regardless of their physical activity levels. Utilizing a standardized, safe, and fully reversible exercise-induced muscle soreness (EIMS) protocol as an experimental pain model, this project will continuously evaluate participants' quantitative sensory testing (QST) profiles and sleep parameters.
The findings from this study will advance the mechanistic understanding of sleep-mediated pain modulation, providing evidence-based insights to inform future targeted sleep management and pain prevention interventions.
The 2 groups in the trial
- Insomnia
Treatment: Eccentric exercise
- Healthy contry
Treatment: Eccentric exercise
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise Induced Muscular Pain: a Case Control Study
- Fit questions
- Built from NCT07827664, who can take part
- Record updated
- 25 September 2026