Text Messages and Automated Calls to Help People With Heart Failure Refill Medicines
Tests text and phone reminders for adults with heart failure overdue on medicine refills.
Plain-language title generated from the registry record
Registry title: Digital Outreach for Heart Failure Adherence
Key facts
- Where
- Pleasanton, United StatesSee the site
Where in United States
- Kaiser Permanente-Division of ResearchPleasanton, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kaiser Permanente
- Trial code
- NCT07831538
- Record updated
- 1 October 2026
- Original description
The goal of the ADHERE-HF study is to evaluate whether care-embedded, operationally delivered digital outreach improves medication refill, adherence, and clinical outcomes among adults with heart failure who are overdue for a refill of an eligible guideline-directed medical therapy (GDMT) medication.Read full original descriptionShow less
Adherence Through Digital Health: Evaluating Randomized Engagement in Heart Failure
The goal of the ADHERE-HF study is to evaluate whether care-embedded, operationally delivered digital outreach improves medication refill, adherence, and clinical outcomes among adults with heart failure who are overdue for a refill of an eligible guideline-directed medical therapy (GDMT) medication.
The main question it aims to answer is: Does digital outreach using interactive text messages or automated telephone calls increase short-term refill of overdue heart failure medications compared with usual care?
The study will evaluate the effectiveness of a digital outreach strategy delivered through existing health system communication channels. Members who have opted in to pharmacy text messaging will receive interactive text messages, while those who have not opted in will receive an interactive automated telephone call. The comparison group will receive usual care with no additional outreach.
Inclusion: Age ≥18 years; Active KPNC membership; Heart failure diagnosis documented at least 6 months before the index date, with a documented EF; Prescribed at least one eligible GDMT medication for ≥6 months:; HFpEF (EF≥50%): ARNI (sacubitril/valsartan); MRA; SGLT2i; HFrEF or HFmrEF (EF <50%): ARNI (sacubitril/valsartan), ACEi, or ARB; Beta-blocker (bisoprolol, carvedilol, or sustained-release metoprolol succinate); MRA; SGLT2i; At least one unfilled refill for an eligible GDMT medication that is 7-13 days overdue at index.
Exclusion: Receiving hospice or comfort-focused care; Skilled nursing facility stay within prior 12 months; Opted out of receiving pharmacy medication adherence outreach from Kaiser Permanente; Documented allergy or intolerance to all eligible GDMT medications for which the patient is overdue; Other conditions that prevent outreach; No valid telephone number on file through which the patient could be reached by text message or automated telephone call.