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Following people in China with memory problems and mood disorders over time

Follows people with cognitive impairment and mood disorders to study risk factors and biomarkers.

Key facts

Who runs it
Xuanwu Hospital, Beijing
Where
Beijing, ChinaSee the site
Trial code
Registry title
Cognition and Affective Research in China
Status
Not yet recruiting
People taking part
3,000 people, planned
Started
1 Oct 2026
Expected to end
30 Jul 2036
Type of study
Observational, 4 groups
Record updated
22 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people with cognitive impairment, mood disorders, behavioral disorders or related disorders, diagnosed under ICD-11. They will be followed over time.

Sex
All sexes can join.
Disease stage
A diagnosis of cognitive impairment, a mood disorder, a behavioral disorder or another related disorder, according to ICD-11.

Main reasons for not taking part

  • Major organ failure (such as heart, liver or kidney failure), cancer, or another condition that limits life expectancy so follow-up cannot be completed
  • A reason that makes an MRI scan unsafe, such as claustrophobia, a pacemaker, aneurysm clips, heart valve prostheses, cochlear implants or other metal implants
  • Refusing to give biological samples
  • Refusing to give written informed consent

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

  • Participants who met the diagnostic criteria for cognitive impairment, mood disorders, behavioral disorders, or other related disorders according to the International Classification of Diseases, 11th Revision (ICD-11)

Who cannot take part

  • 1、Participants with major organ failure (e.g., cardiac, hepatic, or renal failure), malignant tumors, or other conditions associated with a limited life expectancy that would preclude completion of the follow-up; 2、Contraindications to magnetic resonance imaging (MRI), including claustrophobia; implantation of MRI-incompatible devices or metallic implants, such as cardiac pacemakers, aneurysm clips, prosthetic heart valves, cochlear implants, or other metallic foreign bodies; or any other clinical history or examination findings that, in the investigator's judgment, may pose a potential risk during MRI examination; 3、Refusal to provide biological samples. 4、Refusal to provide written informed consent

Where in China

  • Xuanwu HospitalBeijing, ChinaContact: Longfei JiaNo longer taking part

About the trial

What the trial wants to find out

This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive function and neuropsychological assessments, laboratory measurements, and neuroimaging data, along with the collection of blood, urine, feces, and cerebrospinal fluid for biobanking. Multi-omics, multidimensional cognitive assessments, and multimodal neuroimaging data are integrated using statistical analyses to establish a comprehensive clinical database and biobank. The study aims to identify risk factors, elucidate mechanisms underlying the comorbidity of cognitive impairment and mood disorders, discover multimodal biomarkers, and improve early screening, risk prediction, and diagnosis

The 4 groups in the trial

  • Healthy controls

    Healthy volunteers without cognitive impairment, mood disorders, or other major neurological or psychiatric disorders.

  • Patients with cognitive impairment

    Participants who met the diagnostic criteria for cognitive impairment or other related disorders according to the International Classification of Diseases, 11th Revision (ICD-11)

  • Patients with mood disorders

    Participants who met the diagnostic criteria for mood disorders,or other related disorders according to the International Classification of Diseases, 11th Revision (ICD-11).

  • Patients with behavioral disorders

    Participants who met the diagnostic criteria for behavioral disorders or other related disorders according to the International Classification of Diseases, 11th Revision (ICD-11).

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Cognition and Affective Research in China
Plain-language title
Following people in China with memory problems and mood disorders over timeGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
22 September 2026