Integrated Motor-Cognitive Training in Parkinson's Disease: A Feasibility Study
Key facts
- Where
- Ferrara, ItalySee the site
Where in Italy
- Ferrara University HospitalFerrara, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital of Ferrara
- Trial code
- NCT07833748
- Record updated
- 22 September 2026
- Original description
Parkinson's disease is a progressive neurodegenerative condition characterized by both motor symptoms (such as bradykinesia, rigidity, tremor, and postural instability) and non-motor symptoms, including cognitive impairments (affecting working memory, executive functions, and attention). Combined interventions that target both domains simultaneously or consecutively have shown potential to produce superior benefits compared to isolated motor or cognitive training.Read full original descriptionShow less
Parkinson's disease is a progressive neurodegenerative condition characterized by both motor symptoms (such as bradykinesia, rigidity, tremor, and postural instability) and non-motor symptoms, including cognitive impairments (affecting working memory, executive functions, and attention). Combined interventions that target both domains simultaneously or consecutively have shown potential to produce superior benefits compared to isolated motor or cognitive training.
The purpose of this study is to evaluate the feasibility, adherence, and preliminary clinical results of efficacy of an integrated and combined motor-cognitive rehabilitation training in patients diagnosed with Parkinson's disease.
This feasibility study will enroll 12 participants with Parkinson's disease. All participants will undergo a comprehensive 10-session integrated rehabilitation program combining digital cognitive individual stimulation and group functional motor training. The primary focus is to assess acceptability, safety, and adherence to this combined approach, while secondary outcomes will observe changes in relevant cognitive and motor clinical variables.
Inclusion: Diagnosis of Parkinson's disease; Presence of motor symptoms attributable to Parkinson's disease; Availability to participate in both treatments (cognitive and motor); Severity of symptoms compatible with participation in group physical therapy; Absence of other medical conditions that could interfere with treatment delivery; Montreal Cognitive Assessment (MoCA) score >= 18; Consent to participate in group-based motor training; Absence of falls in the 3 months prior to baseline evaluation.
Exclusion: Concomitant major neurological or psychiatric disorders; Changes in baseline pharmacological therapy within 3 months prior to enrollment; Severe cardio-pulmonary, renal, or hepatic diseases.