NCT07839936Not yet recruitingPhase 2
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of VERVE-102, a One-Time Dose Gene Editing Medicine, in Adults With or at High Risk for Atherosclerotic Cardiovascular Disease (ASCVD) Who Require Additional Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering
Source: ClinicalTrials.gov · Last updated 24 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 175 (estimated)
- First submitted
- 18 Sept 2026
- Start date
- Oct 2026
- Primary completion date
- Aug 2028
- Lead sponsor
- Verve Therapeutics, Inc.
- NCT number
- NCT07839936
- EU CT number
- 2026-525691-26-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 175
- From Oct 2026 to the primary completion date, Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current treatment with PCSK9 inhibitor or prior treatment within specified timeframe
Other illness
- History of confirmed or suspected homozygous familial hypercholesterolemia (HoFH)
- Chronic liver disease
Who the study is looking for
- Established atherosclerotic cardiovascular disease (ASCVD) and/or at a high risk of ASCVD
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Epic Medical Research Coordinator of this site? Confirm its status | DeSoto | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.