Testing TRB-001 in people with early Parkinson's disease
Tests TRB-001 against a placebo in people with early Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Assessment of the Safety, Immunogenicity, and Pharmacodynamics of TRB-001 in Patients With Early Idiopathic Parkinson's Disease
Key facts
- Where
- Marburg, GermanySee the site
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
- Has a doctor told you that you have a different condition with similar signs, such as multiple system atrophy or progressive supranuclear palsy?
- How long ago were you diagnosed with Parkinson's disease?
- Do you have dementia, or serious problems with memory and thinking?
- Do you have an ongoing infection with hepatitis B, hepatitis C or HIV?
Source: NCT07840027, who can take part
Where in Germany
- Philipps-Universitaet MarburgMarburg, GermanyNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Tridem Bioscience FlexCo
- Trial code
- NCT07840027EU 2024-519123-14-00
- Record updated
- 24 September 2026
- Original description
This is a randomized, placebo-controlled, double-blind, dose-finding phase 1b study with the purpose to assess the safety, immunogenicity and pharmacodynamics of TRB-001 in early idiopathic Parkinson's Disease patients.Read full original descriptionShow less
A Randomized, Placebo-controlled, Double-blind, Dose-finding Phase 1b Study to Assess the Safety, Immunogenicity and Pharmacodynamics of TRB-001 in Early Idiopathic Parkinson's Disease Patients
This is a randomized, placebo-controlled, double-blind, dose-finding phase 1b study with the purpose to assess the safety, immunogenicity and pharmacodynamics of TRB-001 in early idiopathic Parkinson's Disease patients.
Inclusion: Female or male patients aged 40-75 years old. Refer to section 5.3 for reproductive criteria for male and female participants; Diagnosed with idiopathic PD within the previous 4 years based on the MDS-PD criteria. The diagnosis must be confirmed by bradykinesia plus one of the other cardinal signs (resting tremor, rigidity or postural instability not caused by primary visual, vestibular, cerebellar, or proprioceptive dysfunction) being present; Severity ≤2 in the modified Hoehn and Yahr scale; Brain magnetic resonance imaging (MRI) results should be consistent with the diagnosis of PD; If on symptomatic PD medications (L-DOPA (+/- benserazide, carbidopa), COMT inhibitors (entacapone, opicapone), dopamine agonists (pramipexol, ropinirole, rotigotine, apomorphine), MAO-B inhibitors (safinamid, selegiline, rasagiline) or NMDA receptor antagonists (amantadine)), doses must be stable for at least 3 months before study entry; Understands and agrees to comply with the study procedures and provides written informed consent.
Exclusion: Any relevant systemic illness. This includes cardiovascular, hepatic, gastroenterological, respiratory, endocrinological, hematologic disease, or any other condition that, in the investigator's opinion, could interfere with the analyses of safety and efficacy in this study, unless patient has been on stable doses of medication for any of these concurrent illnesses for at least 3 months prior to study entry; Unstable psychiatric illness, including psychosis, suicidal ideation, untreated major depression, schizophrenia, or bipolar affective disorder within 90 days before Visit 1, as determined by the investigator; Participation in the active treatment phase of any non-PD clinical trial within 30 days prior to Visit 1; Prior treatment with experimental immunotherapeutics for PD, immunosuppressive drugs or treatment with deep brain stimulation. Patient has received or plans to receive any vaccine other than study intervention within 28 days before or 28 days after each study vaccination; Known or suspected allergy, or history of anaphylaxis, to vaccines or their excipients, or kanamycin, if considered relevant by the investigator; Presence or history of autoimmune disease or immunodeficiency, if considered relevant by the investigator; Presence of active infectious disease (hepatitis B, hepatitis C, or human immunodeficiency virus (HIV)); Significant cognitive impairment or clinical dementia, or a Montreal Cognitive Assessment (MoCA) score <26; High suspicion of other parkinsonian syndromes, such as multiple system atrophy, progressive supranuclear palsy, drug induced Parkinsonism and post-encephalitic Parkinsonism; History of drug or alcohol abuse within the past 5 years; Birthmarks, tattoos, wounds, or skin conditions that may obscure the assessment of injection site reactions; Recent history (≤2 years) of cancer (exceptions: basal cell carcinoma, intraepithelial cervical neoplasia); Contraindication for MRI or lumbar puncture; Female patients who are pregnant or lactating; Employee at the study site, spouse/partner or relative of any study staff (e.g., investigator, sub-investigators, or study nurse) or relationship to the sponsor.