Risk-Based Lung Cancer Detection in COPD Patients
Key facts
- Where
- Vejle, DenmarkSee the site
Where in Denmark
- Vejle Hospital, University Hospital of Southern DenmarkVejle, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vejle Hospital
- Trial code
- NCT07848815
- Record updated
- 30 September 2026
- Original description
The goal of the interventional study is to evaluate whether risk-based stratification using the PLCOm2012 model and a machine learning (ML) model can identify patients with chronic obstructive pulmonary disease (COPD) who are at high risk of developing lung cancer and may benefit from low-dose computed tomography (LDCT) screening. The study population includes adults aged 50 years and older with COPD and a history of smoking attending an outpatient clinic.Read full original descriptionShow less
Early Lung Cancer Detection in High-Risk Patients With Risk-Based Machine Learning Models and Biomarkers
The goal of the interventional study is to evaluate whether risk-based stratification using the PLCOm2012 model and a machine learning (ML) model can identify patients with chronic obstructive pulmonary disease (COPD) who are at high risk of developing lung cancer and may benefit from low-dose computed tomography (LDCT) screening. The study population includes adults aged 50 years and older with COPD and a history of smoking attending an outpatient clinic.
The main question it aims to answer are:
- What is the incidence of histopathologically confirmed lung cancer following risk-based stratification?
Participants will:
* Undergo lung cancer risk assessment using the PLCOm2012 model and an ML-based model based on clinical and laboratory data * Be referred for LDCT if classified as high-risk * Continue standard care if classified as low-risk * Be followed through electronic health records for up to six years to assess outcomes including lung cancer incidence, adherence to LDCT, time to imaging, healthcare utilization, costs, and safety
Inclusion: Diagnosed with COPD; Age ≥ 50 years; Attendance at the outpatient Respiratory Medicine clinic, Vejle Hospital, University Hospital of Southern Denmark; Smoking history (current or former smoker); Consent to translational research and biobank.
Exclusion: Previous diagnosis of lung cancer within the last five years; Active treatment for cancer within the last 12 months except non-melanoma skin cancer and carcinoma in situ cervicis uteri; Invasive methods to verify potential lung cancer not an option; Inability to provide informed consent.