Postoperative Delirium and Analgesia in Elderly Patients
Key facts
- Who runs it
- Ankara City Hospital Bilkent
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 300 people, planned
- Started
- 1 Oct 2026
- Expected to end
- 15 Jun 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- adductor canal block and biFes block including bupivacain
- Periarticular infiltration
- Record updated
- 28 October 2026
Who can take part
- Age
- 60 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 20 criteriaShow less
Who can take part
- Patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia
- ASA physical status I-III
- Age ≥60 years
- Body mass index (BMI) between 18-30 kg/m²
- Preoperative fasting duration of approximately 8 hours
Who cannot take part
- Acute myocardial infarction within the previous 12 months before surgery
- Psychiatric or neurological disorders causing cognitive dysfunction (e.g., epilepsy, schizophrenia, dementia, Alzheimer's disease)
- Use of psychotropic or opioid medications, or a history of alcohol abuse or withdrawal within the last 6 months
- History of cranio-cerebral surgery
- Refusal to participate in the study or inability to provide written informed consent
- American Society of Anesthesiologists (ASA) physical status IV or higher
- Obese patients (BMI >30 kg/m²) or cachectic patients (BMI <18 kg/m²)
- Patients requiring general anesthesia or in whom spinal anesthesia could not be achieved
- Contraindications to spinal anesthesia
- Emergency surgeries
- Mini-Mental State Examination (MMSE) score ≤24
- Stage III-IV hepatic encephalopathy
- Severe impairments preventing cognitive assessment, such as blindness or severe hearing loss
- Patients meeting delirium criteria according to baseline 3D-CAM assessment or unable to complete the test
- Requirement for postoperative intensive care unit admission
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
The 2 groups in the trial
- Adductor canal block and BiFes blockExisting treatment, for comparison
Participants in this arm received postoperative analgesia via ultrasound-guided adductor canal block combined with BiFes block using 20 mL of 0.25% bupivacaine for each block following total knee arthroplasty under spinal anesthesia.
Treatment: adductor canal block and biFes block including bupivacain
- Periarticular infiltrationExisting treatment, for comparison
Participants in this arm received postoperative analgesia with periarticular infiltration consisting of 100 mg bupivacaine, 40 mg methylprednisolone, 0.5 mg adrenaline and salin solution during total knee arthroplasty under spinal anesthesia.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effects of Different Analgesic Approaches on Postoperative Delirium in Elderly Patients Undergoing Total Knee Arthroplasty
- Record updated
- 28 October 2026