Studying metabolism and nutrition in people with motor neurone disease
Observes whether metabolism and nutrition checks are workable in adults with motor neurone disease.
Plain-language title generated from the registry record
Registry title: Metabolism and Nutrition in MND
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- Guy's & St Thomas' NHS Foundation TrustLondon, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guy's and St Thomas' NHS Foundation Trust
- Trial code
- NCT07851714
- Record updated
- 1 October 2026
- Original description
Motor neurone disease (MND) is a progressive neurological condition that can affect movement, speech, swallowing and breathing. Weight loss and malnutrition are common in people with MND and may be caused by factors including swallowing difficulties, reduced food intake, fatigue, breathlessness, loss of muscle mass and changes in the amount of energy the body uses at rest.Read full original descriptionShow less
An Observational Study of Metabolism and Nutrition in Motor Neurone Disease (MND): Understanding Determinants of Weight Loss
Motor neurone disease (MND) is a progressive neurological condition that can affect movement, speech, swallowing and breathing. Weight loss and malnutrition are common in people with MND and may be caused by factors including swallowing difficulties, reduced food intake, fatigue, breathlessness, loss of muscle mass and changes in the amount of energy the body uses at rest.
Resting energy expenditure can be measured using indirect calorimetry. However, there is limited evidence about whether comprehensive metabolic, nutritional and body composition assessments can be completed acceptably and practically by people with MND during routine clinical appointments.
MET-MND is a single-centre observational feasibility study involving approximately 12-15 adults with MND referred to a specialist respiratory service. Participants will complete one study visit aligned with a routine clinic appointment, followed by a 7-day food diary at home.
The study will evaluate the acceptability, tolerability, practicality, completion and data completeness of metabolic, nutritional and body composition assessments. Findings will be used to refine study procedures and inform the design of future research investigating metabolism and nutrition in people with MND.
Inclusion: Adult MND patients aged 18 years or over at the time of giving consent; Newly referred to the specialist respiratory service for assessment.
Exclusion: Inability to understand the study's protocol (cognitive disorders); Lacking capacity to provide fully informed written consent, verbal consent (for those who cannot provide written consent), or consent via the use of a communication aid.