NCT07854899Recruiting
Natural History Study of Advanced RCD
External Control, preScreening, and naTurAl hiStory of Advanced retInal Degeneration Due to Rod-cone Dystrophy (ECSTASI)
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
ECSTASI is a Natural History Study, which will be monitoring how standard of care (SoC) affect advanced rod-cone dystrophy (RCD), a type of eye disease also known as retinitis pigmentosa. No experimental, investigational or any other drug or treatment will be tested during the study. This study collects information in 3 parts: Part 1: retrospective health information from medical records (up to past 10 years), Part 2: prospective health information from in-person visits (up to 1 year), and Part 3: prospective health information from medical records (up to 1 year). Participants will decide if they wish to participate in all or only to some of these parts.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 17 Aug 2026
- Start date
- Sept 2026
- Primary completion date
- Sept 2028
- Lead sponsor
- SparingVision
- Diseases
- Retinitis pigmentosa
- NCT number
- NCT07854899
What you commit to
- Study type: Interventional
- Planned participants: 100
- From Sept 2026 to the primary completion date, Sept 2028
- 3 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who are receiving or have received an investigational medicinal product (IMP) in another clinical trial are excluded from the prospective part . However, they can participate in the retrospective part of the study.
Lab values
- Individuals with a medical condition (systemic or ophthalmic), psychiatric condition (including substance abuse disorder), physical examination or laboratory findings that may in the opinion of the Investigator preclude adherence to the scheduled study visits, safe participation in the study, or affect study results are excluded from participating in in-person study visits. However, they can participate in the collection of data reported during both retrospective and prospective SoC routine eye examinations.
Who the study is looking for
- Males and females 18 years of age or older, with history of formed vision
- Clinical diagnosis of advanced retinal degeneration due to RCD
- BCVA no better than (≥) 1.0 LogMAR (≤35 Early-Treatment Diabetic Retinopathy Study \[ETDRS\] letters, or 20/200 Snellen equivalent) in at least one eye
- Documented preservation of foveal Outer Nuclear Layer (ONL) in at least one eye
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ghent university hospital Coordinator of this site? Confirm its status | Ghent | Belgium | Recruiting |
| CHNO XV-XX Paris - CIC 1423 Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| Royal Victoria Eye And Ear Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.