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Two nerve procedures compared for knee osteoarthritis pain

Compares cryoneurolysis with bipolar radiofrequency ablation for knee pain in osteoarthritis.

Plain-language title generated from the registry record
Registry title: Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis

Key facts

Where
Cairo, EgyptSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 40 or older with painful knee osteoarthritis that has not improved with usual care. It compares two nerve treatments for knee pain.

Age
40 years or older
Sex
All sexes
Disease stage
Knee osteoarthritis with pain, visible on X-ray as Kellgren-Lawrence grade III-IV. Knee pain for at least 3-6 months. Pain score (NRS) of 5 or more despite conservative treatment.
Earlier treatment
Conservative treatment did not control the pain. Cannot have had genicular nerve ablation before.
Biomarker or test result
A diagnostic genicular nerve block must have given more than 50% pain relief.

Main reasons for not taking part

  • Earlier genicular nerve ablation
  • Bleeding or clotting disorder (coagulopathy)
  • Local infection
  • Severe knee deformity
  • Neuropathic pain syndromes

Read by machine on 12 November 2026.

Where in Egypt

  • Cairo UniversityCairo, EgyptContact: Ahmed S Abdelgalil, MDTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
National Cancer Institute, Egypt
Trial code
NCT07855367
Record updated
2 October 2026
Original description
This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.Read full original descriptionShow less

Ultrasound-Guided Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial

This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.

Inclusion: Age ≥ 40 years; Symptomatic knee osteoarthritis (OA) in bladder cancer patient [based on American College of Radiology (ACR) criteria]; Radiological OA (Kellgren-Lawrence grade III-IV); Chronic knee pain ≥ 3-6 months; Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment; Positive diagnostic genicular nerve block (>50% pain relief).

Exclusion: Prior genicular nerve ablation; Local infection; Neuropathic pain syndromes; Coagulopathy; Severe deformity; Uncontrolled comorbidities.

ClinicalTrials.gov NCT07855367