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Iron absorption and loss over time in Thai women with overweight or obesity

Measures how much iron women of different weights take in and lose.

Key facts

Who runs it
Mahidol University
Where
Nakhon Pathom, ThailandSee the site
Trial code
Registry title
Long-term Iron Absorption and Loss in Women
Status
Recruiting
People taking part
64 people, planned
Started
8 May 2025
Expected to end
31 Aug 2028
Type of study
Observational, 2 groups
Record updated
2 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 40-50 years, either of normal weight or overweight/obese, to study how the body takes in and loses iron over a long time.

Age
40 to 50 years
Sex
Women only
Disease stage
Two groups: normal weight (BMI 18.5-22.9 kg/m²) or overweight/obese (BMI ≥25.0 kg/m²). Overweight/obese women need CRP 5.0-25.0 mg/L; normal weight women need CRP <5.0 mg/L.
Earlier treatment
No vitamin or mineral supplements during or within two weeks before the study. No weight-loss program. No regular anti-inflammatory or other medicines (except contraceptives and acne medication).
Biomarker or test result
Hemoglobin ≥12.0 g/dL, inflammation-adjusted serum ferritin <50.0 µg/L, and normal hemoglobin typing.

Main reasons for not taking part

  • Serious illness such as cancer, chronic kidney disease, chronic liver disease or chronic heart failure
  • Pregnant, breastfeeding, or planning pregnancy during the study
  • Chronic infection such as tuberculosis or AIDS
  • Blood transfusion, blood donation or significant blood loss within 6 months before enrollment
  • Heavy menstrual bleeding (>80 mL/day)

The registry criteria, word for word

Show all 4 criteriaShow less

Who can take part

  • Normal weight group; Aged 40-50 years; Normal weight (BMI 18.5-22.9 kg/m²); Hb ≥12.0 g/dL and inflammation-adjusted SFa <50.0 µg/L; CRP <5.0 mg/L; Normal hemoglobin typing; Plans to reside in the study area for >2 years
  • Overweight/obese group; Aged 40-50 years; Overweight or obese [Body Mass Index (BMI) ≥25.0 kg/m²] - the BMI cut-off follows the agreement of countries under the Coordinated Research Project (CRP) E43038 "Using the iron isotope dilution technique to assess the influence of inflammation on long-term iron absorption and loss," supported by the IAEA; Hemoglobin (Hb) ≥12.0 g/dL and inflammation-adjusted serum ferritin (SFa) <50.0 µg/L; C-reactive protein (CRP) between 5.0-25.0 mg/L; Normal hemoglobin typing; Plans to reside in the study area for >2 years

Who cannot take part

  • Normal weight group; Having serious medical conditions such as cancer, chronic kidney disease, chronic liver disease, or chronic heart failure; Having metabolic NCDs (e.g., diabetes, hyperlipidemia, hypertension) requiring hospitalization; Pregnant, breastfeeding, or planning pregnancy during the study; Chronic infectious disease (e.g., tuberculosis, AIDS); Regular use of anti-inflammatory or other medications (except contraceptives and acne medication); Taking vitamin or mineral supplements during or within two weeks prior to the study; Participating in a weight-loss program; Known intolerance to iron supplements (e.g., vomiting, diarrhea, abdominal pain, bloating, nausea, or allergic reactions such as rash, breathing difficulty, chest tightness, facial or lip swelling); Blood transfusion, blood donation, or significant blood loss during the study or within 6 months before enrollment; Heavy menstrual bleeding (>80 mL/day, calculated from menstrual record)
  • Overweight/obese group; Obesity class II (BMI ≥35.0 kg/m²) with high health risk; Having serious medical conditions such as cancer, chronic kidney disease, chronic liver disease, or chronic heart failure; Having metabolic noncommunicable diseases (e.g., diabetes, hyperlipidemia, hypertension) requiring hospitalization; Pregnant, breastfeeding, or planning pregnancy during the study; Chronic infectious disease (e.g., tuberculosis, AIDS); Regular use of anti-inflammatory or other medications (except contraceptives and acne medication); Taking vitamin or mineral supplements during or within two weeks prior to the study; Participating in a weight-loss program; Known intolerance to iron supplements (e.g., vomiting, diarrhea, abdominal pain, bloating, nausea, or allergic reactions such as rash, breathing difficulty, chest tightness, facial or lip swelling); Blood transfusion, blood donation, or significant blood loss during the study or within 6 months before enrollment; Heavy menstrual bleeding (>80 mL/day, calculated from menstrual record)

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 40 and 50 years old?

Where in Thailand

  • Institute of NutritionNakhon Pathom, ThailandContact: Tippawan Pongcharoen, Ph.D.Taking people

About the trial

What the trial wants to find out

Obese people typically have chronic low-grade inflammation. Based on short-term studies, this inflammation could affect the absorption, utilization, storage, and mobilization of iron, and individuals with inflammation might develop iron deficiency (ID) and anemia when inadequacy of iron intake is presented. The double burden of malnutrition is nowadays emerging as a major public health concern in many countries, including Thailand. Understanding the association of chronic inflammation among people with overweight or obesity (OW/OB) with long-term iron absorption and loss is important for developing appropriate policies and programs to promote iron balance and, consequently, optimal iron status and health outcomes. Since previous reports among Thai women showed a high prevalence of OW/OB and anemia, this study will be conducted to determine the long-term iron absorption and loss among OW/OB free-living women using the iron isotope dilution method.

The 2 groups in the trial

  • Normal weight

    BMI 18.5-22.9 kg/m2

  • Overweight or obesity

    BMI 25-35 kg/m2

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Long-term Iron Absorption and Loss in Overweight/Obese Thai Middle-aged Women
Plain-language title
Iron absorption and loss over time in Thai women with overweight or obesityGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07855939, who can take part
Record updated
2 October 2026