Dexmedetomidine vs Propofol Sedation in Endovascular Aortic Repair
Key facts
- Who runs it
- Bursa City Hospital
- Where
- Türkiye2 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 282 people enrolled
- Started
- 1 Sept 2026
- Ended
- 15 Sept 2026
- Type of study
- Observational, 2 groups
- Treatments tested
- Dexmedetomidine
- propofol
- Record updated
- 5 October 2026
Who can take part
- Age
- 18 years to 90 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Age 18 years or older
- Underwent endovascular aortic repair in the operating room of Bursa City Hospital between 18 October 2019 and 5 August 2026
- Received local anesthesia with dexmedetomidine-based or propofol-based intravenous sedation
Who cannot take part
- General anesthesia
- Emergency procedures
- Missing data in medical records
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Endovascular aortic repair (EVAR) is increasingly performed under local anesthesia with intravenous sedation, but the optimal sedative agent has not been established. Dexmedetomidine provides cooperative sedation with minimal respiratory depression and may have renoprotective effects, whereas propofol is widely used but can cause respiratory depression and hypotension.
Read full original descriptionShow less
This single-center retrospective cohort study compares dexmedetomidine-based and propofol-based sedation in adult patients who underwent EVAR under local anesthesia and sedation at Bursa City Hospital. The primary outcome is postoperative acute kidney injury (AKI) defined by KDIGO serum creatinine criteria. Secondary outcomes include intensive care unit (ICU) admission, ICU length of stay, hospital length of stay, and in-hospital mortality.
The 2 groups in the trial
- Dexmedetomidine Group
Adult patients who underwent elective EVAR under local anesthesia with dexmedetomidine-based intraoperative sedation.
Treatment: Dexmedetomidine
- Propofol Group
Adult patients who underwent elective EVAR under local anesthesia with propofol-based intraoperative sedation.
Treatment: propofol
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison of Dexmedetomidine-Based Versus Propofol-Based Sedation in Endovascular Aortic Repair: A Retrospective Cohort Study
- Record updated
- 5 October 2026