Early access
Sign in
Not yet taking people in United StatesNo phase

Comparing two egg collection methods in each ovary of women with infertility

Compares lab-matured eggs from one ovary with stimulated eggs from the other, in infertile women.

Key facts

Who runs it
New Hope Fertility Center
Where
New York, United StatesSee the site
Trial code
Registry title
Intra-ovarian CAPA-IVM vs Standard IVM
Status
Not yet recruiting
People taking part
20 people, planned
Started
Oct 2026
Expected to end
Oct 2027
Type of study
Interventional
Treatments tested
  • CAPA-IVM
  • In-House CAPA-IVM Pre-Maturation Medium
  • Minimal-Stimulation OS-IVF
Record updated
5 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women having fertility treatment. In each woman, one ovary's eggs are matured in the lab (CAPA-IVM), and the other ovary gets mild stimulation and IVF.

Age
18 to 38 years
Sex
Female only
Disease stage
Infertility treated with assisted reproduction. Both ovaries must be present and usable for egg collection.
Earlier treatment
No earlier removal of an ovary (oophorectomy).
Biomarker or test result
AMH greater than 0.5 ng/mL and more than 6 antral follicles (small egg sacs) per ovary.

Main reasons for not taking part

  • Severe endometriosis, Stage III or IV
  • AMH less than 0.2 ng/mL
  • Active pelvic infection or untreated hydrosalpinx (fluid-blocked fallopian tube)
  • Known chromosome problem in either partner, unless genetic testing is planned
  • Cannot have egg collection or sedation/anesthesia

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Female, age 18 to 38 years
  • Undergoing assisted reproductive treatment for infertility
  • Both ovaries present and anatomically suitable for oocyte retrieval, with no prior oophorectomy
  • Adequate ovarian reserve for study participation, including AMH greater than 0.5 ng/mL and antral follicle count greater than 6 per ovary
  • Both ovaries considered suitable for their assigned study procedures: right ovary for CAPA-IVM and left ovary for minimal-stimulation OS-IVF
  • Access to partner or donor sperm for fertilization/ICSI according to clinic protocol
  • Willing and able to provide written informed consent and comply with study procedures and follow-up

Who cannot take part

  • Active pelvic infection
  • Any medical or gynecologic condition that, in the investigator's judgment, would interfere with study participation, oocyte retrieval, study procedures, or participant safety
  • Severe endometriosis, Stage III or IV
  • Known diminished ovarian reserve with AMH less than 0.2 ng/mL, unless specifically permitted under an approved study amendment
  • Untreated hydrosalpinx
  • Known chromosomal abnormality in either reproductive partner, unless appropriate genetic testing is planned
  • Contraindication to oocyte retrieval or sedation/anesthesia

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 38 years old?

Where in United States

  • New Hope Fertility CenterNew York, United StatesContact: Clinical CoordinatorsNot yet recruiting

About the trial

What the trial wants to find out

This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a two-step biphasic capacitation in vitro maturation method (CAPA-IVM). Beginning on Day 5 of the same menstrual cycle, the left ovary undergoes minimal controlled ovarian stimulation followed by routine oocyte retrieval and IVF/ICSI.

Read full original descriptionShow less

The primary objective is to evaluate the maturation of CAPA-IVM oocytes to the metaphase II (MII) stage and compare reproductive laboratory outcomes between the CAPA-IVM and minimal-stimulation OS-IVF approaches. Secondary outcomes include fertilization, embryo development, blastocyst formation, embryo quality, pregnancy and live birth outcomes, and safety.

The group in the trial

  • Within-Patient CAPA-IVM and Minimal-Stimulation OS-IVFTreatment being tested

    All participants undergo a within-patient comparison in the same menstrual cycle. The right ovary undergoes retrieval of immature oocytes for CAPA-IVM beginning on or after menstrual cycle Day 3, before ovarian stimulation. The left ovary subsequently undergoes minimal controlled ovarian stimulation beginning on Day 5, followed by oocyte retrieval and standard IVF/ICSI. Outcomes are compared according to ovary and oocyte origin, with each participant serving as her own internal control.

    Treatment: CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, and Minimal-Stimulation OS-IVF

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Within-Patient Comparison of CAPA-IVM (Biphasic Capacitation IVM) With the Contralateral Ovary Undergoing Minimal Controlled Ovarian Stimulation (OS-IVF)
Plain-language title
Comparing two egg collection methods in each ovary of women with infertilityGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 15 November 2026.
Fit questions
Built from NCT07858435, who can take part
Record updated
5 October 2026