Comparing a new heart CT scan with in-artery imaging for plaque risk

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 79 with stable coronary artery disease. A recent photon-counting CT scan must show a lesion that needs more checking and may be treated with a stent (PCI).

Age

18 to 79 years

Sex

All sexes

Disease stage

Stable coronary syndrome. A recent photon-counting CT angiography scan showed at least one lesion that needs more evaluation with intravascular imaging or fractional flow reserve, and PCI under IVUS guidance is considered possible.

Earlier treatment

No previous coronary artery bypass surgery and no previous heart transplantation.

Main reasons for not taking part

• Acute coronary syndrome within the last 3 months
• Kidney failure (eGFR <60ml/min/1.73m²)
• Decompensated heart failure, or left ventricular ejection fraction ≤30%
• Pregnancy
• Needs surgical revascularisation, or extensive coronary disease or twisting arteries that block the imaging

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 18 and 79 years old?YesNo

What the trial wants to find out

Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK. Despite existing therapies, adverse cardiovascular events remains high, especially in patients who have already had a heart attack, as some of these patients have aggressive atherosclerotic disease. If we could identify these vulnerable patients, then in wider clinical practice in the future we might be able to treat them better with new therapies that can otherwise be expensive or come with a risk of side-effects. Traditionally, the assessment of atherosclerotic disease and the identification of the plaques that will cause heart attacks is performed using invasive imaging - imaging taken by passing a wire into the arteries of the heart that has a camera on its tip. Invasive imaging, however, can be used only in patients with symptoms and has risks. Photon counting (PC) CT is a new CT system that has image quality comparable to invasive imaging and can be used in the community to examine individuals with stable angina symptoms. In this study we aim to compare how well PC-CT detects high-risk plaques compared with invasive imaging and in due course develop a platform that will expedite the analysis of CT images to allow its broad use in the clinical practice.

The group in the trial

• Patients with Chronic Coronary Syndrome

  Treatment: observational study