Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery
Key facts
- Who runs it
- Peter Gaarsdal Uhrbrand
- Where
- Denmark1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 242 people, planned
- Started
- 1 Oct 2026
- Expected to end
- 14 Apr 2027
- Type of study
- Observational, 2 groups
- Record updated
- 9 October 2026
Who can take part
- Age
- 65 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Patients at least 65 years of age undergoing surgery for hip fracture in general or spinal anesthesia
- Treated during the defined pre- or post-implementation period
Who cannot take part
- Known hypersensitivity to dexmedetomidine
- Acute cerebral conditions with potentially impaired cerebral autoregulation
- Acute or chronic liver failure
- Second- or third-degree AV block without pacemaker
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications. Patients with hip fracture are often elderly, acutely admitted, in pain, and have multiple comorbidities, all of which increase the risk of delirium.
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This study evaluates whether implementation of intraoperative dexmedetomidine prophylaxis reduces postoperative delirium in patients undergoing hip fracture surgery. The study will compare patients treated before and after implementation of dexmedetomidine prophylaxis.
The 2 groups in the trial
- Pre-implementation
Patients undergoing hip fracture surgery before implementation of intraoperative dexmedetomidine prophylaxis.
- Post-implementation / Dexmedetomidine prophylaxis
Patients undergoing hip fracture surgery after implementation of intraoperative dexmedetomidine prophylaxis. Dexmedetomidine prophylaxis is initiated after induction of general anesthesia or after spinal anesthesia has been established. Patients receive dexmedetomidine bolus 0.5 µg/kg ideal body weight followed by infusion 0.5 µg/kg/hour. The infusion is discontinued at the end of surgery.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Intraoperative Dexmedetomidine for Prevention of Postoperative Delirium in Patients Undergoing Hip Fracture Surgery: a Pre-post Study
- Record updated
- 9 October 2026