NCT07868458CompletedPhase 4
Randomized, Controlled Study to Investigate the 12-month Efficacy and Safety of Resveratrol Vitamin Supplements in Patients With Non-proliferative Diabetic Retinopathy Without Center Involved Diabetic Macular Edema (REVOLUTION Study)
Randomized, Controlled Study to Investigate the 12-month Efficacy and Safety of Resveratrol Vitamin Supplements in Patients With Non-proliferative Diabetic Retinopathy Without Center Involved Diabetic Macular Edema
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
This randomized, controlled study aims to investigate the efficacy and safety of resveratrol-containing vitamin supplements in patients with non-proliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (DME). Patients with diabetes mellitus and NPDR attending the Second Department of Ophthalmology will be enrolled and randomly assigned to a supplementation or control group. During the 12-month follow-up period, the study will evaluate the potential effects of resveratrol supplementation on diabetic retinopathy, including changes in disease severity and progression, while also monitoring its safety and tolerability.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 5 Oct 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- University of Athens
- Diseases
- Diabetic eye disease
- NCT number
- NCT07868458
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 100
- From 30 Sept 2026 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Corneal or lens disorders that may interfere with ophthalmological examinations or imaging.
- Other ocular diseases that may affect study outcomes.
Age
- Age-related macular degeneration (AMD).
Other
- Proliferative diabetic retinopathy (PDR).
- Center-involved diabetic macular edema (DME).
- Retinal vein occlusion.
- Uncontrolled glaucoma (intraocular pressure \>30 mmHg).
- Uveitis.
Who the study is looking for
- Patients diagnosed with type 2 diabetes mellitus (T2DM).
- Presence of non-proliferative diabetic retinopathy (NPDR), classified according to the International Clinical Diabetic Retinopathy Disease Severity Scale (DRSS).
- Absence of center-involved diabetic macular edema (DME).
- Provision of written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Second Department of Ophthalmology, School of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.