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US-Guided Saphenous Block in Knee OA

Key facts

Who runs it
Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Where
Ankara, TürkiyeSee the site
Trial code
Status
Not yet recruiting
People taking part
60 people, planned
Started
2 Oct 2026
Expected to end
30 Nov 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Intra-articular corticosteroid injection
  • Ultrasound-Guided High-Volume Saphenous Nerve Block
  • Home-Based Exercise Program
Record updated
9 October 2026

Who can take part

Age
40 years to 75 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Patients aged between 40 and 75 years
  • Diagnosis of primary knee osteoarthritis according to the American College of Rheumatology (ACR) criteria
  • Kellgren-Lawrence grade 2 or 3 knee osteoarthritis on weight-bearing radiographs
  • Moderate to severe knee pain (Visual Analog Scale score ≥ 4/10) lasting for at least 3 months
  • Willingness and ability to participate in the study and sign the written informed consent form

Who cannot take part

  • Previous knee surgery or arthroplasty on the target knee
  • Coagulopathy or ongoing anticoagulant therapy
  • History of intra-articular corticosteroid injection in the target knee within the past 3 months
  • Severe systemic diseases, active infection, or localized skin infection at the injection site
  • Known allergy or hypersensitivity to local anesthetics, triamcinolone acetonide, or bupivacaine
  • Severe cognitive impairment or inability to comply with follow-up protocols and home exercises
  • History of intra-articular hyaluronic acid or platelet-rich plasma (PRP) injection in the target knee within the past 6 months
  • Kellgren-Lawrence grade 1 or grade 4 knee osteoarthritis
  • Secondary knee osteoarthritis (e.g., post-traumatic, inflammatory arthritis, gout, septic arthritis)

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 40 and 75 years old?

Where in Türkiye

  • Ankara Gaziler Physical Medicine and Rehabilitation Training and Research HospitalAnkara, TürkiyeContact: MUHAMMET EMIR ACAR, MDNo longer taking part

About the trial

What the trial wants to find out

The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with intra-articular corticosteroid injection compared to intra-articular corticosteroid injection alone in patients with Kellgren-Lawrence Grade 3-4 medial compartment knee osteoarthritis (OA) refractory to conservative treatment.

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A total of 60 participants aged 45-75 years will be randomly assigned (1:1) into two treatment arms:

* Group 1: US-guided intra-articular corticosteroid injection (40 mg triamcinolone acetonide + 1 mL saline) + home exercise program. * Group 2: US-guided intra-articular corticosteroid injection + US-guided high-volume saphenous nerve block (10 mL 0.2% bupivacaine solution) + home exercise program.

Clinical assessments (WOMAC, VAS, and SF-36) will be conducted at baseline (T0), 1st month (T1), 3rd month (T2), and 6th month (T3). Sonographic evaluations, including saphenous nerve cross-sectional area (CSA) and perineural vascularity via Power Doppler US, will be performed at baseline (T0), 1st month (T1), and 6th month (T3). The primary outcome is functional improvement measured by the change in WOMAC total score.

The 2 groups in the trial

  • Group 1: Intra-articular Corticosteroid InjectionExisting treatment, for comparison

    Participants will receive a US-guided intra-articular corticosteroid injection consisting of 40 mg (1 mL) triamcinolone acetonide mixed with 1 mL 0.9% saline (total volume 2 mL) via a suprapatellar lateral approach. Participants will also perform a standardized 4-week home-based exercise program.

    Treatment: Intra-articular corticosteroid injection and Home-Based Exercise Program

  • Group 2: Intra-articular Corticosteroid + High-Volume Saphenous Nerve BlockTreatment being tested

    Participants will receive a US-guided intra-articular corticosteroid injection (40 mg triamcinolone acetonide + 1 mL 0.9% saline, total 2 mL) combined with a US-guided high-volume saphenous nerve block (10 mL bupivacaine solution, \~0.2% final concentration, prepared with 8 mL 0.25% bupivacaine and 2 mL 0.9% saline) at the adductor canal/mid-thigh level. Participants will also perform a standardized 4-week home-based exercise program.

    Treatment: Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, and Home-Based Exercise Program

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Evaluation of the Clinical and Sonographic Effects of Ultrasound-Guided Saphenous Nerve Block in Knee Osteoarthritis
Fit questions
Built from NCT07868770, who can take part
Record updated
9 October 2026