Blood sugar swings after two weight-loss surgeries in adults with severe obesity
Compares blood sugar swings after two weight-loss surgeries in adults with severe obesity.
Plain-language title generated from the registry record
Registry title: Glycemic Variability After SASI Versus Roux-en-Y Gastric Bypass
Key facts
- Where
- Seville, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 74 years old?
Source: NCT07872397, who can take part
Where in Spain
- Hospital Universitario Virgen del RocioSeville, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospitales Universitarios Virgen del Rocío
- Trial code
- NCT07872397
- Record updated
- 13 October 2026
- Original description
The GLUBARI trial is a prospective, randomized, single-center clinical study comparing two bariatric surgical procedures in adults with morbid obesity: Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass (RYGB). The main objective is to compare glycemic variability between the two procedures using continuous glucose monitoring. Participants will undergo continuous glucose monitoring for 7 days before surgery and again at 6 and 12 months after surgery. Secondary outcomes include hypoglycemic events, weight loss, resolution of obesity-related comorbidities, postoperative complications, gastroesophageal reflux, nutritional deficiencies, and quality of life. A total of 68 participants will be randomized in a 1:1 ratio to SASI or RYGB and followed for 12 months after surgery.Read full original descriptionShow less
Comparison of Glycemic Variability After Bariatric Surgery With Single Anastomosis Sleeve Ileal Bypass (SASI) Versus Roux-en-Y Gastric Bypass (RYGB) Using Continuous Glucose Monitoring
The GLUBARI trial is a prospective, randomized, single-center clinical study comparing two bariatric surgical procedures in adults with morbid obesity: Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass (RYGB). The main objective is to compare glycemic variability between the two procedures using continuous glucose monitoring. Participants will undergo continuous glucose monitoring for 7 days before surgery and again at 6 and 12 months after surgery. Secondary outcomes include hypoglycemic events, weight loss, resolution of obesity-related comorbidities, postoperative complications, gastroesophageal reflux, nutritional deficiencies, and quality of life. A total of 68 participants will be randomized in a 1:1 ratio to SASI or RYGB and followed for 12 months after surgery.
Inclusion: Age 18 years or older and younger than 75 years; Morbid obesity with body mass index (BMI) between 35 and 55 kg/m²; Pre-anesthetic assessment classified as ASA I-III; Signed informed consent.
Exclusion: Previous major gastrointestinal surgery; Pre-anesthetic assessment not suitable for surgery or ASA IV; Pathological gastroesophageal reflux disease with endoscopic involvement; Active malignancy; Diseases that alter interstitial fluid volume and may affect glucose measurement accuracy, including severe acute or chronic renal failure, heart failure, or liver failure; Body mass index (BMI) >55 kg/m²; Pregnancy; Alcohol addiction; Refusal to sign informed consent; Inability to comply with study instructions.'.