NCT07873931Not yet recruitingPhase 1
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
A Phase 1, Multicenter, Open-Label Study of BMS-986553, CD19 In Vivo Chimeric Antigen Receptor (CAR) T Cells, in Participants With Refractory Autoimmune Diseases
Source: ClinicalTrials.gov · Last updated 14 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Sjögren's disease (SjD).
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 8 Oct 2026
- Start date
- 30 Oct 2026
- Primary completion date
- 20 Oct 2032
- Lead sponsor
- Bristol-Myers Squibb
- NCT number
- NCT07873931
- EudraCT number
- 2026-525936-41
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 60
- From 30 Oct 2026 to the primary completion date, 20 Oct 2032
- 23 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants must not have other systemic immune disorders. Other protocol-defined Inclusion/Exclusion criteria apply.
Who the study is looking for
- SLE participants: Must have diagnosis of SLE defined as fulfilling the 2019 ACR/EULAR classification criteria of SLE.
- IIM participants: Must have diagnosis of IIM defined as fulfilling the 2017 ACR/EULAR classification criteria for probable or definite IIM.
- SSc participants: Must have diagnosis of SSc defined as fulfilling 2013 ACR/EULAR classification criteria for SSc.
- RA participants: Must have diagnosis of RA, defined as fulfilling 2010 ACR/EULAR criteria for RA.
- Primary SjD Participants: Must have diagnosis fulfilling the 2016 ACR/EULAR Classification Criteria.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (23)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0029 Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
| Local Institution - 0028 Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Local Institution - 0060 Coordinator of this site? Confirm its status | Erlangen | Germany | Unknown status |
| Local Institution - 0059 Coordinator of this site? Confirm its status | Magdeburg | Germany | Unknown status |
| Local Institution - 0027 Coordinator of this site? Confirm its status | Würzburg | Germany | Unknown status |
| Local Institution - 0039 Coordinator of this site? Confirm its status | Montpellier | France | Unknown status |
| Local Institution - 0047 Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Local Institution - 0055 Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Local Institution - 0063 Coordinator of this site? Confirm its status | Leiden | Netherlands | Unknown status |
| Local Institution - 0051 Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Unknown status |
| Local Institution - 0050 Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
| Local Institution - 0046 Coordinator of this site? Confirm its status | Poznan | Poland | Unknown status |
| Local Institution - 0004 Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Local Institution - 0052 Coordinator of this site? Confirm its status | Great Neck | United States | Unknown status |
| Local Institution - 0007 Coordinator of this site? Confirm its status | Morristown | United States | Unknown status |
| Local Institution - 0064 Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| Local Institution - 0062 Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Local Institution - 0008 Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Local Institution - 0013 Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Local Institution - 0015 Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Local Institution - 0005 Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Local Institution - 0003 Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.