Light Resistance Training With Blood Flow Restriction for Muscle Weakness After Colorectal Cancer
Tests light strength training with and without blood flow restriction in colorectal cancer survivors.
Plain-language title generated from the registry record
Registry title: Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
Key facts
- Where
- Cairo, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 59 years old?
Source: NCT07874035, who can take part
Where in Egypt
- Private ClinicsCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ahmed Adel Ahmed Elsayed Ali Radwan
- Trial code
- NCT07874035
- Record updated
- 21 October 2026
- Original description
PURPOSE:Read full original descriptionShow less
Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
PURPOSE:
To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
BACKGROUND:
Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited.
HYPOTHESES:
It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
RESEARCH QUESTION:
Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
Inclusion: Colorectal cancer with probable sarcopenia; Age 40-59 years; Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (>15 seconds without upper limb support); Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability; Medical clearance for supervised exercise; Ability to follow instructions and complete assessments.
Exclusion: Uncontrolled cardiovascular disease or hypertension; Severe peripheral vascular disease; Uncontrolled treatment-related complications, such as severe anemia or infection; Metastatic bone disease in the lower limbs; Neurological or musculoskeletal disorders limiting safe participation; Any contraindication to resistance or blood flow restriction training; Recent thromboembolic events.