Comparison of the Therapeutic Effects of Lyophilized Platelet-rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis
Key facts
- Who runs it
- Taichung Veterans General Hospital
- Where
- Taiwan1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- Phase
- Phase 2
- People taking part
- 39 people enrolled
- Started
- 1 Jan 2024
- Ended
- 22 Jul 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Lyophilized Platelet-rich Plasma Lysate
- Dextrose Prolotherapy
- Record updated
- 21 October 2026
Who can take part
- Age
- 20 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Patients with radiographically confirmed knee osteoarthritis of Kellgren-Lawrence grade III or lower; Patients older than 20 years of age; Patients who are willing to provide written informed consent
Who cannot take part
- Platelet dysfunction; Thrombocytopenia; Hypofibrinogenemia; Hemodynamic instability; Sepsis; Acute or chronic infectious diseases; History of chronic liver disease; Current anticoagulant therapy; Long-term or excessive use of aspirin or vitamin E; History of HIV infection, syphilis, or other legally notifiable infectious diseases; Cognitive impairment that prevents compliance with study procedures or medical instructions
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this clinical trial is to compare the therapeutic effects of lyophilized platelet-rich plasma lysate and dextrose prolotherapy in patients with knee osteoarthritis (OA). The main questions it aims to answer are:
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* Does lyophilized platelet-rich plasma lysate improve pain, physical function, and muscle strength in patients with knee osteoarthritis? * Is lyophilized platelet-rich plasma lysate more effective than dextrose prolotherapy in improving clinical outcomes in patients with knee osteoarthritis?
Researchers will compare patients receiving lyophilized platelet-rich plasma lysate with those receiving dextrose prolotherapy to evaluate differences in treatment effectiveness.
Participants will:
* Receive intra-articular injections of either lyophilized platelet-rich plasma lysate or dextrose prolotherapy. * Undergo clinical assessments before and after treatment, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to evaluate pain, stiffness, and physical function. * Undergo knee X-ray examinations to assess osteoarthritis severity using the Kellgren-Lawrence (KL) grading system. * Undergo isokinetic muscle strength testing using a Biodex dynamometer to evaluate knee muscle strength.
The 2 groups in the trial
- Lyophilized Platelet-rich Plasma LysateTreatment being tested
- Dextrose ProlotherapyExisting treatment, for comparison
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison of the Therapeutic Effects of Lyophilized Platelet-Rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis
- Record updated
- 21 October 2026