Modified Ketogenic Diet Study for Drug-Resistant Epilepsy in Adults
Tests a modified ketogenic diet in adults whose epilepsy does not respond to medicines.
Plain-language title generated from the registry record
Registry title: Modified Ketogenic Diet on Drug-Resistant Epilepsy in Adults - a Prospective Observational Study of Real-world Data
Key facts
- Where
- Stockholm, SwedenSee the site
Where in Sweden
- Karolinska InstitutetStockholm, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Karolinska Institutet
- Trial code
- NCT07878104
- Record updated
- 16 October 2026
- Original description
The purpose of our study is to investigate how dietary treatment with a modified ketogenic diet for patients with drug-resistant epilepsy affects patients' health-related quality of life and seizure frequency. We will also examine the diet's impact on cognitive functions, sleep, treatment side effects, microbiota metabolites, inflammation, and changes in the gut and oral bacterial flora, as well as the long-term aspects of this dietary treatment.Read full original descriptionShow less
Modified Ketogenic Diet on Drug-Resistant Epilepsy in Adults - a Prospective Observational Study of Real-world Data
The purpose of our study is to investigate how dietary treatment with a modified ketogenic diet for patients with drug-resistant epilepsy affects patients' health-related quality of life and seizure frequency. We will also examine the diet's impact on cognitive functions, sleep, treatment side effects, microbiota metabolites, inflammation, and changes in the gut and oral bacterial flora, as well as the long-term aspects of this dietary treatment.
Inclusion: Age 18 years or older; Drug-resistant epilepsy (seizures not adequately controlled despite two or more antiepileptic drugs at adequate doses); Historical seizure frequency of six or more per year.
Exclusion: Lack of motivation to treatment with modified ketogenic diet; Severe psychiatric comorbidity , dementia, or severe functional impairment impacting adherence without a next of kin for support with diet; Type 1 Diabetes; Gallbladder disease; Liver disease; Metabolic disease; Kidney disease; Pregnancy; Body mass index (BMI) below 19.