Modified Ketogenic Diet Study for Drug-Resistant Epilepsy in Adults
Tests a modified ketogenic diet in adults whose epilepsy does not respond to medicines.
Plain-language title generated from the registry record
Registry title: Modified Ketogenic Diet on Drug-Resistant Epilepsy in Adults - a Prospective Observational Study of Real-world Data
Key facts
- Where
- Stockholm, SwedenSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults whose epilepsy is not controlled by medicines. They would try a modified ketogenic diet, and the study will look at quality of life and seizures.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Drug-resistant epilepsy: seizures not well controlled despite two or more antiepileptic drugs at adequate doses. Six or more seizures per year in the past.
- Earlier treatment
- Two or more antiepileptic drugs at adequate doses that did not control the seizures.
Main reasons for not taking part
- Not motivated to follow the modified ketogenic diet
- Severe psychiatric illness, dementia or severe functional impairment, without a next of kin to help with the diet
- Pregnancy
- Type 1 diabetes, gallbladder, liver, metabolic or kidney disease
- Body mass index (BMI) below 19
Read by machine on 12 November 2026.
Where in Sweden
- Karolinska InstitutetStockholm, SwedenContact: Ann-Sofie Rudberg, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Karolinska Institutet
- Trial code
- NCT07878104
- Record updated
- 16 October 2026
- Original description
The purpose of our study is to investigate how dietary treatment with a modified ketogenic diet for patients with drug-resistant epilepsy affects patients' health-related quality of life and seizure frequency. We will also examine the diet's impact on cognitive functions, sleep, treatment side effects, microbiota metabolites, inflammation, and changes in the gut and oral bacterial flora, as well as the long-term aspects of this dietary treatment.Read full original descriptionShow less
Modified Ketogenic Diet on Drug-Resistant Epilepsy in Adults - a Prospective Observational Study of Real-world Data
The purpose of our study is to investigate how dietary treatment with a modified ketogenic diet for patients with drug-resistant epilepsy affects patients' health-related quality of life and seizure frequency. We will also examine the diet's impact on cognitive functions, sleep, treatment side effects, microbiota metabolites, inflammation, and changes in the gut and oral bacterial flora, as well as the long-term aspects of this dietary treatment.
Inclusion: Age 18 years or older; Drug-resistant epilepsy (seizures not adequately controlled despite two or more antiepileptic drugs at adequate doses); Historical seizure frequency of six or more per year.
Exclusion: Lack of motivation to treatment with modified ketogenic diet; Severe psychiatric comorbidity , dementia, or severe functional impairment impacting adherence without a next of kin for support with diet; Type 1 Diabetes; Gallbladder disease; Liver disease; Metabolic disease; Kidney disease; Pregnancy; Body mass index (BMI) below 19.