Comparing body fat and muscle distribution in women with lipedema and women without it
Compares body fat and muscle distribution in women with and without lipedema.
Plain-language title generated from the registry record
Registry title: Comparison of Segmental Body Composition Characteristics in Lipedema and Obesity
Key facts
- Where
- Istanbul, TürkiyeSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women aged 18 to 65. One group has lipedema. The other group has obesity without lipedema and is similar in age and BMI.
- Age
- 18 to 65 years
- Sex
- Women only
- Disease stage
- Lipedema group: lipedema diagnosed on clinical examination. Comparison group: does not meet the criteria for lipedema on clinical examination.
Main reasons for not taking part
- Pregnant or breastfeeding
- Primary or secondary lymphedema
- Advanced chronic venous insufficiency, active venous ulcer, or past acute deep vein thrombosis
- Surgery or serious injury in the last 6 months
- Active infection, cellulitis, or open wound
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07878299, who can take part
Where in Türkiye
- Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital, Istanbul, UskudarIstanbul, TürkiyeContact: Feyza Yücel Assoc.Prof.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
- Trial code
- NCT07878299
- Record updated
- 16 October 2026
- Original description
The aim of this study is to compare the total and regional body composition characteristics of women with lipedema and women without lipedema who are matched for age and body mass index, as determined by the TANITA MC-580 segmental bioelectrical impedance analysis (BIA) device. In addition to total fat mass and fat percentage, fat mass, fat-free mass, and muscle mass measurements of the right and left legs, right and left arms, and trunk are planned to be evaluated. From these measurements, regional distribution indicators such as the proportion of lower extremity fat mass within total body fat, the leg-to-trunk fat ratio, the leg-to-arm fat ratio, and the leg muscle-to-fat ratio will be calculated. In addition, the study aims to examine the relationships between segmental body composition characteristics and disease type and stage, disease duration, pain severity, and lower extremity function in the lipedema group.Read full original descriptionShow less
Comparison of Segmental Body Composition Characteristics in Lipedema and Obesity: A Body Mass Index-Matched Bioelectrical Impedance Analysis Study
The aim of this study is to compare the total and regional body composition characteristics of women with lipedema and women without lipedema who are matched for age and body mass index, as determined by the TANITA MC-580 segmental bioelectrical impedance analysis (BIA) device. In addition to total fat mass and fat percentage, fat mass, fat-free mass, and muscle mass measurements of the right and left legs, right and left arms, and trunk are planned to be evaluated. From these measurements, regional distribution indicators such as the proportion of lower extremity fat mass within total body fat, the leg-to-trunk fat ratio, the leg-to-arm fat ratio, and the leg muscle-to-fat ratio will be calculated. In addition, the study aims to examine the relationships between segmental body composition characteristics and disease type and stage, disease duration, pain severity, and lower extremity function in the lipedema group.
Hypothesis: The proportion of total body fat located in the lower extremities is significantly higher in women with lipedema compared to women without lipedema matched for age and body mass index.
Inclusion: Inclusion Criteria (Lipedema Group); Being female; Being between 18-65 years of age; Having received a diagnosis of lipedema based on clinical evaluation; Being willing to participate in the study and signing the written informed consent form; Inclusion Criteria (BMI-Matched Obese Group); Being female; Being between 18-65 years of age; Not meeting the diagnostic criteria for lipedema on clinical evaluation; Showing similar characteristics to the lipedema group in terms of age and BMI; Being willing to participate in the study and signing the written informed consent form.
Exclusion: Having clinically advanced-stage chronic venous insufficiency, an active venous ulcer, or a history of acute deep vein thrombosis; Having a history of surgery or serious trauma within the last 6 months; Having an active infection, cellulitis, or open wound; Presence of edema due to congestive heart failure, advanced renal failure, or decompensated liver disease; Having a diagnosis of active malignancy; Having a neurological, rheumatological, or serious musculoskeletal disease that could affect the assessment; Being pregnant or breastfeeding; Having a diagnosis of primary or secondary lymphedema; Being unable to comply with study procedures or not providing informed consent.